ID   MC007_MCV1              Reviewed;         217 AA.
AC   Q98178;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   12-AUG-2020, entry version 44.
DE   RecName: Full=Protein MC007;
GN   Name=MC007;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT   "Recombination events and variability among full-length genomes of co-
RT   circulating molluscum contagiosum virus subtypes 1 and 2.";
RL   J. Gen. Virol. 0:0-0(2017).
RN   [3]
RP   INTERACTION WITH HOST RB1, MOTIF, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=18701596; DOI=10.1128/jvi.01187-08;
RA   Mohr S., Grandemange S., Massimi P., Darai G., Banks L., Martinou J.C.,
RA   Zeier M., Muranyi W.;
RT   "Targeting the retinoblastoma protein by MC007L, gene product of the
RT   molluscum contagiosum virus: detection of a novel virus-cell interaction by
RT   a member of the poxviruses.";
RL   J. Virol. 82:10625-10633(2008).
CC   -!- FUNCTION: Plays a role in the modulation of host cell cycle. Induces a
CC       cytoplasmic sequestration of host RB1 at the mitochondrial membrane.
CC       {ECO:0000269|PubMed:18701596}.
CC   -!- SUBUNIT: Interacts with host RB1; this interaction induces the
CC       cytosolic sequestration of RB1. {ECO:0000269|PubMed:18701596}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion membrane
CC       {ECO:0000269|PubMed:18701596}.
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DR   EMBL; U60315; AAC55135.1; -; Genomic_DNA.
DR   EMBL; KY040275; AQY16746.1; -; Genomic_DNA.
DR   EMBL; KY040276; AQY16927.1; -; Genomic_DNA.
DR   EMBL; KY040277; AQY17106.1; -; Genomic_DNA.
DR   PIR; T30609; T30609.
DR   RefSeq; NP_043958.1; NC_001731.1.
DR   GeneID; 1487028; -.
DR   KEGG; vg:1487028; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0044191; C:host cell mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Host membrane; Host mitochondrion; Host-virus interaction; Membrane;
KW   Modulation of host cell cycle by virus; Reference proteome.
FT   CHAIN           1..217
FT                   /note="Protein MC007"
FT                   /id="PRO_0000444800"
FT   MOTIF           141..145
FT                   /note="LXCXE motif"
FT                   /evidence="ECO:0000269|PubMed:18701596"
SQ   SEQUENCE   217 AA;  22983 MW;  7A6909126B510098 CRC64;
     MHAELAEVAA AVSAAACIVG LRHARPGCAR AFVAGALVSS VGYTCFPAIR HCVHMAARYL
     SYLCFVRGGA TACVHSVADE AVQELVDSLH RVLAERDQCV LGSVELVQGS EPLVLGLPQA
     PVLCVPEPSG AVDPECVEVD LYCHENLRYE SDVSEDEDKD DACDEGISLA RQTLLDLLAC
     SEDASGFSPP EDSFSSLLET GELYDEVLDA SLARAEA