ID   MC132_MCV1              Reviewed;         229 AA.
AC   Q98298;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   23-FEB-2022, entry version 44.
DE   RecName: Full=Protein MC132;
GN   Name=MC132;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT   "Recombination events and variability among full-length genomes of co-
RT   circulating molluscum contagiosum virus subtypes 1 and 2.";
RL   J. Gen. Virol. 0:0-0(2017).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST RELA; CUL5; ELOB
RP   AND ELOC.
RX   PubMed=26041281; DOI=10.1128/jvi.00799-15;
RA   Brady G., Haas D.A., Farrell P.J., Pichlmair A., Bowie A.G.;
RT   "Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B
RT   activation by targeting p65 for degradation.";
RL   J. Virol. 89:8406-8415(2015).
CC   -!- FUNCTION: Inhibits host NF-kappa-B activation stimulated by IL-1 and
CC       multiple PRR viral detection pathways. Targets host NF-kappa-B
CC       component RELA/p65 for ubiquitin-dependent proteasomal degradation.
CC       {ECO:0000269|PubMed:26041281}.
CC   -!- SUBUNIT: Interacts with host RELA (via RHD domain), ELOB, ELOC and
CC       CUL5; these interactions induce the proteasomal degradation of host
CC       RELA. {ECO:0000269|PubMed:26041281}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:26041281}.
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DR   EMBL; U60315; AAC55260.1; -; Genomic_DNA.
DR   EMBL; KY040275; AQY16881.1; -; Genomic_DNA.
DR   EMBL; KY040276; AQY17060.1; -; Genomic_DNA.
DR   EMBL; KY040277; AQY17239.1; -; Genomic_DNA.
DR   PIR; T30734; T30734.
DR   RefSeq; NP_044083.1; NC_001731.1.
DR   GeneID; 1487151; -.
DR   KEGG; vg:1487151; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus; Reference proteome.
FT   CHAIN           1..229
FT                   /note="Protein MC132"
FT                   /id="PRO_0000444798"
SQ   SEQUENCE   229 AA;  26276 MW;  A028A7DC4E7105F9 CRC64;
     MMNFSDPCLL GPSACNEDFF EELAREILPT PEAKALAARL LRRLGWHPSE GQCSWCPEAY
     EYLYDLQFRY TGPVPLVRKH PGSALIVRWM LDGLGHFLFC RPRVQGNPLT YHLSCMGSAI
     RTLELFREQA HSHLWEQGNL VDCYWSCSSD YGYEGKWGQQ AVVRGALSGP WPRPDPPSLQ
     LQCLCAIWRT CLLRGQSQAQ KYTNWICARH LQLRPDTSTR DSDLLLQRC