MC132_MCV1
ID MC132_MCV1 Reviewed; 229 AA.
AC Q98298;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 23-FEB-2022, entry version 44.
DE RecName: Full=Protein MC132;
GN Name=MC132;
OS Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX NCBI_TaxID=10280;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT host response-evasion genes.";
RL Science 273:813-816(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT "Recombination events and variability among full-length genomes of co-
RT circulating molluscum contagiosum virus subtypes 1 and 2.";
RL J. Gen. Virol. 0:0-0(2017).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST RELA; CUL5; ELOB
RP AND ELOC.
RX PubMed=26041281; DOI=10.1128/jvi.00799-15;
RA Brady G., Haas D.A., Farrell P.J., Pichlmair A., Bowie A.G.;
RT "Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B
RT activation by targeting p65 for degradation.";
RL J. Virol. 89:8406-8415(2015).
CC -!- FUNCTION: Inhibits host NF-kappa-B activation stimulated by IL-1 and
CC multiple PRR viral detection pathways. Targets host NF-kappa-B
CC component RELA/p65 for ubiquitin-dependent proteasomal degradation.
CC {ECO:0000269|PubMed:26041281}.
CC -!- SUBUNIT: Interacts with host RELA (via RHD domain), ELOB, ELOC and
CC CUL5; these interactions induce the proteasomal degradation of host
CC RELA. {ECO:0000269|PubMed:26041281}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:26041281}.
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DR EMBL; U60315; AAC55260.1; -; Genomic_DNA.
DR EMBL; KY040275; AQY16881.1; -; Genomic_DNA.
DR EMBL; KY040276; AQY17060.1; -; Genomic_DNA.
DR EMBL; KY040277; AQY17239.1; -; Genomic_DNA.
DR PIR; T30734; T30734.
DR RefSeq; NP_044083.1; NC_001731.1.
DR GeneID; 1487151; -.
DR KEGG; vg:1487151; -.
DR Proteomes; UP000000869; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host-virus interaction;
KW Inhibition of host NF-kappa-B by virus; Reference proteome.
FT CHAIN 1..229
FT /note="Protein MC132"
FT /id="PRO_0000444798"
SQ SEQUENCE 229 AA; 26276 MW; A028A7DC4E7105F9 CRC64;
MMNFSDPCLL GPSACNEDFF EELAREILPT PEAKALAARL LRRLGWHPSE GQCSWCPEAY
EYLYDLQFRY TGPVPLVRKH PGSALIVRWM LDGLGHFLFC RPRVQGNPLT YHLSCMGSAI
RTLELFREQA HSHLWEQGNL VDCYWSCSSD YGYEGKWGQQ AVVRGALSGP WPRPDPPSLQ
LQCLCAIWRT CLLRGQSQAQ KYTNWICARH LQLRPDTSTR DSDLLLQRC