ID   MC148_MCV1              Reviewed;         104 AA.
AC   Q98314; O12616; O12897;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Chemokine-like protein MC148;
GN   Name=MC148;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9208457; DOI=10.1023/a:1007991508159;
RA   Moratilla M., Agromayor M., Nunez A., Funes J.M., Varas A.J.,
RA   Lopez-Estebaranz J.L., Esteban M., Martin-Gallardo A.;
RT   "A random DNA sequencing, computer-based approach for the generation of a
RT   gene map of Molluscum contagiosum virus.";
RL   Virus Genes 14:73-80(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT   "Recombination events and variability among full-length genomes of co-
RT   circulating molluscum contagiosum virus subtypes 1 and 2.";
RL   J. Gen. Virol. 0:0-0(2017).
RN   [4]
RP   FUNCTION.
RX   PubMed=9275219; DOI=10.1073/pnas.94.18.9875;
RA   Krathwohl M.D., Hromas R., Brown D.R., Broxmeyer H.E., Fife K.H.;
RT   "Functional characterization of the C---C chemokine-like molecules encoded
RT   by molluscum contagiosum virus types 1 and 2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:9875-9880(1997).
RN   [5]
RP   FUNCTION.
RX   PubMed=9600978; DOI=10.1073/pnas.95.11.6403;
RA   Damon I., Murphy P.M., Moss B.;
RT   "Broad spectrum chemokine antagonistic activity of a human poxvirus
RT   chemokine homolog.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:6403-6407(1998).
RN   [6]
RP   FUNCTION.
RX   PubMed=10620615; DOI=10.1084/jem.191.1.171;
RA   Luettichau H.R., Stine J., Boesen T.P., Johnsen A.H., Chantry D.,
RA   Gerstoft J., Schwartz T.W.;
RT   "A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the
RT   poxvirus molluscum contagiosum.";
RL   J. Exp. Med. 191:171-180(2000).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH HOST CXCL12.
RX   PubMed=21802105; DOI=10.1016/j.virol.2011.07.001;
RA   Jin Q., Altenburg J.D., Hossain M.M., Alkhatib G.;
RT   "Role for the conserved N-terminal cysteines in the anti-chemokine
RT   activities by the chemokine-like protein MC148R1 encoded by Molluscum
RT   contagiosum virus.";
RL   Virology 417:449-456(2011).
CC   -!- FUNCTION: Plays a role in antagonizing the chemotaxis of multiple
CC       leukocyte subsets induced by CC and CXC chemokines. Displaces the
CC       interaction between CXCL12 and CXCR4 and thereby inactivates the
CC       antiviral activity of host CXCL12 (PubMed:21802105).
CC       {ECO:0000269|PubMed:10620615, ECO:0000269|PubMed:21802105,
CC       ECO:0000269|PubMed:9275219, ECO:0000269|PubMed:9600978}.
CC   -!- SUBUNIT: Interacts with host CXCL12. {ECO:0000269|PubMed:21802105}.
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DR   EMBL; U86945; AAB58019.1; -; Genomic_DNA.
DR   EMBL; U60315; AAC55276.1; -; Genomic_DNA.
DR   EMBL; KY040275; AQY16898.1; -; Genomic_DNA.
DR   EMBL; KY040277; AQY17256.1; -; Genomic_DNA.
DR   PIR; T30750; T30750.
DR   RefSeq; NP_044099.1; NC_001731.1.
DR   SMR; Q98314; -.
DR   GeneID; 1487167; -.
DR   KEGG; vg:1487167; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0039553; P:suppression by virus of host chemokine activity; IDA:UniProtKB.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   Pfam; PF00048; IL8; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Inhibition of host chemokines by virus;
KW   Reference proteome; Viral immunoevasion.
FT   CHAIN           1..104
FT                   /note="Chemokine-like protein MC148"
FT                   /id="PRO_0000444801"
SQ   SEQUENCE   104 AA;  11471 MW;  63DDC3183AA5E987 CRC64;
     MRGGDVFASV VLMLLLALPR PGVSLARRKC CLNPTNRPIP NPLLQDLSRV DYQAIGHDCG
     REAFRVTLQD GRQGCVSVGN KSLLDWLRGH KDLCPQIWSG CESL