ID   MC160_MCV1              Reviewed;         371 AA.
AC   Q98326;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein MC160;
GN   Name=MC160;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid 2016_7;
RA   Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT   "Recombination events and variability among full-length genomes of co-
RT   circulating molluscum contagiosum virus subtypes 1 and 2.";
RL   J. Gen. Virol. 0:0-0(2017).
RN   [3]
RP   INTERACTION WITH HOST CASP8 AND FADD, AND FUNCTION.
RX   PubMed=11259186; DOI=10.1006/viro.2001.0834;
RA   Shisler J.L., Moss B.;
RT   "Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP
RT   protein blocks Fas-induced activation of procaspases and degradation of the
RT   related MC160 protein.";
RL   Virology 282:14-25(2001).
RN   [4]
RP   FUNCTION, DOMAIN, AND INTERACTION WITH HOST HSP90AA1 AND CASP8.
RX   PubMed=16378960; DOI=10.1128/jvi.80.2.578-586.2006;
RA   Nichols D.B., Shisler J.L.;
RT   "The MC160 protein expressed by the dermatotropic poxvirus molluscum
RT   contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB
RT   activation via inhibition of I kappa kinase complex formation.";
RL   J. Virol. 80:578-586(2006).
RN   [5]
RP   FUNCTION.
RX   PubMed=19158250; DOI=10.1128/jvi.02009-08;
RA   Nichols D.B., Shisler J.L.;
RT   "Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB
RT   activation mediated via components of the tumor necrosis factor receptor 1
RT   signal transduction pathway.";
RL   J. Virol. 83:3162-3174(2009).
RN   [6]
RP   FUNCTION.
RX   PubMed=28425034; DOI=10.1007/s11262-017-1456-9;
RA   Beaury M., Velagapudi U.K., Weber S., Soto C., Talele T.T., Nichols D.B.;
RT   "The molluscum contagiosum virus death effector domain containing protein
RT   MC160 RxDL motifs are not required for its known viral immune evasion
RT   functions.";
RL   Virus Genes 53:522-531(2017).
CC   -!- FUNCTION: Plays a role in inhibition of host innate immune response.
CC       Reduces TNF-alpha-mediated NF-kappa-B activation. Interferes with IKK
CC       kinase activity and reduces the phosphorylation of both components
CC       CHUK/IKKA and IKBKB/IKKB. {ECO:0000269|PubMed:11259186,
CC       ECO:0000269|PubMed:16378960, ECO:0000269|PubMed:19158250,
CC       ECO:0000269|PubMed:28425034}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with host HSP90AA1
CC       (PubMed:11259186). Interacts (via N-terminus) with host CASP8
CC       (PubMed:11259186, PubMed:16378960). Interacts with host FADD
CC       (PubMed:11259186). {ECO:0000269|PubMed:11259186,
CC       ECO:0000269|PubMed:16378960}.
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DR   EMBL; U60315; AAC55288.1; -; Genomic_DNA.
DR   EMBL; KY040277; AQY17272.1; -; Genomic_DNA.
DR   PIR; T30762; T30762.
DR   RefSeq; NP_044111.1; NC_001731.1.
DR   SMR; Q98326; -.
DR   GeneID; 1487018; -.
DR   KEGG; vg:1487018; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IDA:UniProtKB.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IDA:UniProtKB.
DR   Gene3D; 1.10.533.10; -; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR002398; Pept_C14.
DR   PANTHER; PTHR10454; PTHR10454; 1.
DR   SMART; SM00031; DED; 2.
DR   SUPFAM; SSF47986; SSF47986; 2.
DR   PROSITE; PS50168; DED; 2.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Inhibition of host NF-kappa-B by virus;
KW   Reference proteome.
FT   CHAIN           1..371
FT                   /note="Protein MC160"
FT                   /id="PRO_0000444797"
FT   DOMAIN          6..76
FT                   /note="DED 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00065,
FT                   ECO:0000269|PubMed:16378960"
FT   DOMAIN          93..169
FT                   /note="DED 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00065,
FT                   ECO:0000269|PubMed:16378960"
SQ   SEQUENCE   371 AA;  38626 MW;  48123BADD29667AB CRC64;
     MAHEPIPFSF LRNLLAELDA SEHEVLRFLC RDVAPASKTA EDALRALQRR RLLTLSSMAE
     LLCALRRFDV LKVRFGMTRE CAGRLLGHGF LSQYRLQVAA INNMVGSEDL RVMCLCAGKL
     LPPSCTPRCL VDLVSALEDA GAISPQDVSV LVTLLHAVCR YDLSVALSAV AHGHMTVGVG
     TPVQDEPMDV LEVDDAEPME ATPACDEIGV VKLAGAASAG APLADGAFAA CTSAGKGEDL
     ATSDLTDSEP EDSVFAVADP VYADVDLSMF VRANATADSS MFVNADAGAD SSLVNADAGA
     DSSLVNADAG ADSSLVNAVA DANSSLMRTT SACTDSEPED SAGPSCAGMA LSMFGRAKSV
     SSLLLRTKAS Y