ID   MC163_MCV1              Reviewed;         620 AA.
AC   Q98329;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=Apoptosis regulator MC163R;
GN   Name=MC163R;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28235685; DOI=10.1016/j.virol.2017.02.017;
RA   Coutu J., Ryerson M.R., Bugert J., Brian Nichols D.;
RT   "The molluscum contagiosum virus protein MC163 localizes to the
RT   mitochondria and dampens mitochondrial mediated apoptotic responses.";
RL   Virology 505:91-101(2017).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis. Prevents
CC       host TNF-alpha-induced mitochondrial membrane permeabilization and
CC       reduces caspase-3/CASP3 and PARP1 cleavage induced by the intrinsic
CC       apoptotic pathway. {ECO:0000269|PubMed:28235685}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion {ECO:0000269|PubMed:28235685}.
CC       Host membrane {ECO:0000255}; Single-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; U60315; AAC55291.1; -; Genomic_DNA.
DR   PIR; T30765; T30765.
DR   RefSeq; NP_044114.1; NC_001731.1.
DR   GeneID; 1487021; -.
DR   KEGG; vg:1487021; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   SUPFAM; SSF101912; SSF101912; 1.
PE   3: Inferred from homology;
KW   Host membrane; Host mitochondrion; Host-virus interaction; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..620
FT                   /note="Apoptosis regulator MC163R"
FT                   /id="PRO_0000443230"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   620 AA;  65905 MW;  D72A3EBDFBDE9096 CRC64;
     MGPRAQRARS TLRKLRRALC GRQDSPARAR TPENRHFARK CARTCEHGYA HTHTCEDTPA
     KEHGHLGEHE CLRGHGHAHA YEERCENKHK HLHAHEHTHE RHGRAPRRLA LTAPLPLLLL
     PLLLPPMILL FFLSPADAKP VLERQVFWNH SEPRASFLTP PHGPGAPPGG PFLTAVGGDG
     TLYLIPSNSS NPPVCVEIPL PYGPGHENVI TLLLVDGGPR TPDALTVAAC LEVGVSLLTT
     NATEPTNASN SSPRLTGSCE KLRTWALGNP PFTRVCGTGG GTPRCWALST NGSIHDLGLD
     GVGYSPPQHN GTRPLLCTNT SEPHLHSCEH TAWNGDHDPQ RCTRTPLDKH GQSWSPQCHK
     STAPNQLGTR PPLLITKMSD ENGTDYVYFL IGGSGDDYPP LLARVCEDDC WLSGHWTPRL
     QTVLQTNVSC ANASALLKST SGNGGPIVLL VEGEGGNGSI CTYSGLDTGK HFAHTPQLGE
     TGPRDPLVGA CGHNGDVPES LAKKAREHPD LKQTLTPSGG PVALPGLDPR HVTALGTGPG
     LLFLGTNQSN VFLLRMNDNG RPNGSLTLFW NGTGNGNGRA GPRGPVLGLQ HSSGGGAGAA
     GLLAVLFGDG VTVLRTEGAL