ID   MC25B_XENLA             Reviewed;         253 AA.
AC   Q5U509;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=MICOS complex subunit mic25-b;
DE   AltName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 6B;
GN   Name=chchd6-b; Synonyms=mic25-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane.
CC       {ECO:0000250|UniProtKB:Q9BRQ6}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex (also known as MINOS or MitOS
CC       complex). {ECO:0000250|UniProtKB:Q9BRQ6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BRQ6}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q9BRQ6}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC       Mic25 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH84878.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC084878; AAH84878.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q5U509; -.
DR   SMR; Q5U509; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR   InterPro; IPR007964; MIC19/MIC25.
DR   Pfam; PF05300; MIC19_MIC25; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Disulfide bond; Lipoprotein; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..253
FT                   /note="MICOS complex subunit mic25-b"
FT                   /id="PRO_0000416912"
FT   DOMAIN          206..248
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   REGION          38..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          87..116
FT                   /evidence="ECO:0000255"
FT   MOTIF           209..219
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           230..240
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   COMPBIAS        38..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        209..240
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        219..230
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   253 AA;  28600 MW;  02C6A96B0EDA0074 CRC64;
     MGGSESTGRK VSFGMDEEER VRVLRGVRLS DEVVTRMKDQ STWAASGAAS GSATVPSKVG
     SSASHPAAAS KDGAHKPTAA GVGHQYAEED LYRRYEREQT LIQEELARLA KREKDAAHQR
     LSTSILREKK MADQERRKAE HLPADLDEWA KDLEHKEAEL QNLNTFYREQ LSSIEKKNLE
     IYRLTEEQFH TAATNAELRV KQRSYDPVCM DLQSNILKCY AENKQERLNC SDLAKEYQKC
     VSAAQKNLLF NHG