MC3R_MOUSE
ID MC3R_MOUSE Reviewed; 323 AA.
AC P33033;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Melanocortin receptor 3;
DE Short=MC3-R;
GN Name=Mc3r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8172596; DOI=10.1042/bj2990367;
RA Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.;
RT "Molecular cloning, functional expression and pharmacological
RT characterization of a mouse melanocortin receptor gene.";
RL Biochem. J. 299:367-373(1994).
RN [2]
RP FUNCTION.
RX PubMed=19036988; DOI=10.1523/jneurosci.3615-08.2008;
RA Sutton G.M., Perez-Tilve D., Nogueiras R., Fang J., Kim J.K., Cone R.D.,
RA Gimble J.M., Tschop M.H., Butler A.A.;
RT "The melanocortin-3 receptor is required for entrainment to meal intake.";
RL J. Neurosci. 28:12946-12955(2008).
CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. This
CC receptor is mediated by G proteins which activate adenylate cyclase.
CC Required for expression of anticipatory patterns of activity and
CC wakefulness during periods of limited nutrient availability and for the
CC normal regulation of circadian clock activity in the brain
CC (PubMed:19036988). {ECO:0000269|PubMed:19036988}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X74983; CAA52918.1; -; Genomic_DNA.
DR CCDS; CCDS17127.1; -.
DR PIR; S43850; S43850.
DR RefSeq; NP_032587.1; NM_008561.3.
DR AlphaFoldDB; P33033; -.
DR SMR; P33033; -.
DR BioGRID; 201340; 1.
DR STRING; 10090.ENSMUSP00000047358; -.
DR BindingDB; P33033; -.
DR ChEMBL; CHEMBL4774; -.
DR GuidetoPHARMACOLOGY; 284; -.
DR GlyGen; P33033; 3 sites.
DR PaxDb; P33033; -.
DR PRIDE; P33033; -.
DR Antibodypedia; 2935; 346 antibodies from 37 providers.
DR DNASU; 17201; -.
DR Ensembl; ENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
DR GeneID; 17201; -.
DR KEGG; mmu:17201; -.
DR UCSC; uc008ocl.1; mouse.
DR CTD; 4159; -.
DR MGI; MGI:96929; Mc3r.
DR VEuPathDB; HostDB:ENSMUSG00000038537; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234510; -.
DR HOGENOM; CLU_009579_13_0_1; -.
DR InParanoid; P33033; -.
DR OMA; TCMKGAV; -.
DR OrthoDB; 1037679at2759; -.
DR PhylomeDB; P33033; -.
DR TreeFam; TF332646; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 17201; 2 hits in 73 CRISPR screens.
DR PRO; PR:P33033; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P33033; protein.
DR Bgee; ENSMUSG00000038537; Expressed in gastrula and 22 other tissues.
DR ExpressionAtlas; P33033; baseline and differential.
DR Genevisible; P33033; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004977; F:melanocortin receptor activity; ISO:MGI.
DR GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IDA:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0017046; F:peptide hormone binding; ISO:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0032922; P:circadian regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0042309; P:homoiothermy; ISO:MGI.
DR GO; GO:0045475; P:locomotor rhythm; IMP:UniProtKB.
DR GO; GO:0008217; P:regulation of blood pressure; ISO:MGI.
DR GO; GO:0060259; P:regulation of feeding behavior; IMP:UniProtKB.
DR GO; GO:0002027; P:regulation of heart rate; ISO:MGI.
DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001908; MC3-5R.
DR InterPro; IPR002122; Mcort_3_rcpt.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR PANTHER; PTHR22750:SF4; PTHR22750:SF4; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR PRINTS; PR00535; MELNOCORTINR.
DR PRINTS; PR01061; MELNOCORTN3R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Melanocortin receptor 3"
FT /id="PRO_0000069719"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 315
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 323 AA; 35806 MW; F4B7B02FA4A87B7B CRC64;
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI VSLMENILVI
LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV INSDSLTLED QFIQHMDNIF
DSMICISLVA SICNLLAIAI DRYVTIFYAL RYHSIMTVRK ALTLIGVIWV CCGICGVMFI
IYSESKMVIV CLITMFFAMV LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG
AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
FRSLELRNTF KEILCGCNSM NLG
