MC5R_PIG
ID MC5R_PIG Reviewed; 294 AA.
AC Q9MZV8;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Melanocortin receptor 5;
DE Short=MC5-R;
DE Flags: Fragment;
GN Name=MC5R;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10895318;
RA Kim K.S., Marklund S., Rothschild M.F.;
RT "The porcine melanocortin-5 receptor (MC5R) gene: polymorphisms, linkage
RT and physical mapping.";
RL Anim. Genet. 31:230-231(2000).
CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The
CC activity of this receptor is mediated by G proteins which activate
CC adenylate cyclase. This receptor is a possible mediator of the
CC immunomodulation properties of melanocortins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF133793; AAF82610.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9MZV8; -.
DR SMR; Q9MZV8; -.
DR STRING; 9823.ENSSSCP00000027505; -.
DR PaxDb; Q9MZV8; -.
DR PRIDE; Q9MZV8; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q9MZV8; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004977; F:melanocortin receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001908; MC3-5R.
DR InterPro; IPR000621; Melancort_rcpt_5.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR PANTHER; PTHR22750:SF5; PTHR22750:SF5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR PRINTS; PR00535; MELNOCORTINR.
DR PRINTS; PR01063; MELNOCORTN5R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN <1..>294
FT /note="Melanocortin receptor 5"
FT /id="PRO_0000069731"
FT TOPO_DOM <1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..>294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 294
SQ SEQUENCE 294 AA; 32753 MW; C6ED78FA26B55D42 CRC64;
FLDLQLNATE GNVSGPSVGN TSSPCEDMGI EVEVFLTLGL ISLLENILVI GAIARNKNLH
VPMYFFVCSL AVADMLVSLS NSWETITIYL IANKHLVLSD TSVRHLDNVF DSMICISLVA
SMCSLLAVAV DRYVTIFYAL RYQHLMTGRR CGAIIAGIWA LCTGCGPVFI VYYESTYVVV
CLVAMFLTML LLMASLYAHM FLQARAHVRR IAALPGYRSA RQRTSMKGAV TLAMLLGVFI
VCWAPFFLHL ILMISCPQNL YCSCFMSHFN MYLILIMCNS VIDPLIYAFR SQEK
