ID   MCA1A_ASPCL             Reviewed;         429 AA.
AC   A1CQZ0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Metacaspase-1A;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casA; ORFNames=ACLA_027860;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW08061.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS027059; EAW08061.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001269487.1; XM_001269486.1.
DR   AlphaFoldDB; A1CQZ0; -.
DR   SMR; A1CQZ0; -.
DR   STRING; 5057.CADACLAP00001846; -.
DR   EnsemblFungi; EAW08061; EAW08061; ACLA_027860.
DR   GeneID; 4702054; -.
DR   KEGG; act:ACLA_027860; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333612"
FT   CHAIN           ?..429
FT                   /note="Metacaspase-1A"
FT                   /id="PRO_0000333613"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        220
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        276
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   429 AA;  47379 MW;  A7DE1A220FFD9457 CRC64;
     MQHHHQGSYG GGGGGGGYPG QAYREQNPYG YGQQSPQQGY GAPQQHNGYN QPPSGYGQPQ
     HNGGQMYGQR QQGMWLRVRI ASRDRKFLTF ALGQYQNHYS HPHQGGPPPP PSEPVAFGHG
     APQGYNFQYS RCTGKRKALM IGINYFGQKG QLRGCINDVK NMSTYLNQNF GYAREDMVLL
     TDDQQNPMSQ PTKANILRAM HWLVKDAQPN DSLFFHYSGH GGQTPDLDGD EEDGYDEVIY
     PVDFRQAGHI VDDEMHRIMV QPLRPGVRLT AIFDSCHSGS ALDLPYIYST QGILKEPNLA
     KEAGQGLLGV VSAYARGDMG SMVSTAVGFL KRAAKGDEAY ERTKQTKTSP ADVIMWSGSK
     DSQTSQDAQI AGQATGAMSW AFISALRKNP QQSYVQLLNS IRDELATKYT QKPQLSCSHP
     LDTNLLYVM