MCA1A_ASPFC
ID MCA1A_ASPFC Reviewed; 413 AA.
AC B0XPP3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Metacaspase-1A;
DE EC=3.4.22.-;
DE Flags: Precursor;
GN Name=casA; ORFNames=AFUB_007090;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Involved in cell death (apoptosis) (By similarity). Required
CC for the apoptotic-like loss of membrane phospholipid asymmetry at
CC stationary phase and facilitates growth under conditions of endoplasmic
CC reticulum stress. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDP56007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS499594; EDP56007.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; B0XPP3; -.
DR SMR; B0XPP3; -.
DR PhylomeDB; B0XPP3; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR SUPFAM; SSF52129; SSF52129; 1.
PE 3: Inferred from homology;
KW Apoptosis; Hydrolase; Protease; Thiol protease; Zymogen.
FT PROPEP 1..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000333616"
FT CHAIN ?..413
FT /note="Metacaspase-1A"
FT /id="PRO_0000333617"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..61
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 204
FT /evidence="ECO:0000250"
FT ACT_SITE 260
FT /evidence="ECO:0000250"
SQ SEQUENCE 413 AA; 45199 MW; 571774D794E201D5 CRC64;
MQNHHHQQSS YGGGYPGQAY REQHPPPNPY GYGQPSPQPG YGAPPPHNGY GQPPSGYGQP
PPPTGNAVYG GRQPGMNQYQ NTYSHGHQGG PPPPPTDPVA FGHGAPQGYS FQYSRCTGKR
KALLIGINYF GQKGQLRGCI NDVKNMSTYL NQNFGYARED MVLLTDDQQN PMSQPTKANI
LRAMHWLVKD AQPNDSLFFH YSGHGGQTPD LDGDEEDGYD EVIYPVDFRQ AGHIVDDEMH
RIMVRPLRPG VRLTAIFDSC HSGSALDLPY IYSTQGILKE PNLAKEAGQG LLGVVSAYAR
GDMSGMVSTA VGFLKRATKG DEAYTRSKQT KTSPADVIMW SGSKDSQTSQ DAQIGGQATG
AMSWAFITAL RKNPQQSYVQ LLNSIRDELA TKYSQKPQLS CSHPLDTNLL YVM