ID   MCA1A_ASPOR             Reviewed;         419 AA.
AC   Q2UN81;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Metacaspase-1A;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casA; ORFNames=AO090001000470;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; AP007154; BAE56984.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2UN81; -.
DR   SMR; Q2UN81; -.
DR   STRING; 510516.Q2UN81; -.
DR   MEROPS; C14.035; -.
DR   EnsemblFungi; BAE56984; BAE56984; AO090001000470.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333628"
FT   CHAIN           ?..419
FT                   /note="Metacaspase-1A"
FT                   /id="PRO_0000333629"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        190
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        246
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   419 AA;  46374 MW;  8D72C7754E6FD750 CRC64;
     MHHQQSSYGG GYPGQAYRQQ QPNNAYGYGQ PSPQPYGSHH NGYNSPQQNY GPPSGGHMYQ
     QQSAYQNSYN QGGHGIPARP PDQPVSFGQG APQEYAYRYS ACTGTRKALL IGINYFNQKG
     QLRGCINDVK NMSTYLHENF GYPRENMVLL TDDQQNPKSQ PTKANILRAM HWLVKDAKPN
     DSLFFHYSGH GGQTPDLDGD EDDGYDEVIY PVDFRQAGHI VDDEMHRIMV NPLQPGVRLT
     AIFDSCHSGS ALDLPYIYST QGILKEPNLA KEAGQGLLGV VSAYARGDMG SMVSTAVGFF
     KKATKGDEVY ERNKQTKTSG ADVIMWSGSK DDQTSQDAQI QGQATGAMSW AFISALRKNP
     QQSYVQLLNS IRDELSTKYT QKPQLSCSHP LGDLIDVPVL GSGFIWFWVL SIFQCQATK