MCA1A_ASPTN
ID MCA1A_ASPTN Reviewed; 403 AA.
AC Q0CTN3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Metacaspase-1A;
DE EC=3.4.22.-;
DE Flags: Precursor;
GN Name=casA; ORFNames=ATEG_02951;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAU36225.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CH476597; EAU36225.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001212129.1; XM_001212129.1.
DR AlphaFoldDB; Q0CTN3; -.
DR SMR; Q0CTN3; -.
DR STRING; 341663.Q0CTN3; -.
DR EnsemblFungi; EAU36225; EAU36225; ATEG_02951.
DR GeneID; 4317427; -.
DR eggNOG; KOG1546; Eukaryota.
DR OrthoDB; 821819at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR SUPFAM; SSF52129; SSF52129; 1.
PE 3: Inferred from homology;
KW Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW Zymogen.
FT PROPEP 1..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000333632"
FT CHAIN ?..403
FT /note="Metacaspase-1A"
FT /id="PRO_0000333633"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..49
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 194
FT /evidence="ECO:0000250"
FT ACT_SITE 250
FT /evidence="ECO:0000250"
SQ SEQUENCE 403 AA; 44206 MW; 8661A6AA24646C61 CRC64;
MQHHHHSSYG GGGGGYPGQA YRQQQPYYGQ PSPQPYAQPP PPNYQRPSGY GPPPSGGHMY
QQGPPAPYQQ HNSYQGGHGR PAPPPTDPVA FGHGAPQGYN FQYSRCTGKR KALLIGINYF
GQKGQLRGCI NDVKNMSTYL NQNFGYARED MVLLTDDQQN PMSQPTKANI LRAMHWLVKD
AQPNDSLFFH YSGHGGQTPD LDGDEDDGYD EVIYPVDFRV AGHIVDDEMH RIMVNPLKPG
TRLTAIFDSC HSGSALDLPY IYSTQGILKE PNLAKEAGQG LLGVVSAYAR GDMGSMVSTA
VGFLKKAAKG DEAYERTKQT KTSPADVIMW SGSKDSQTSS DAQIQGQATG AMSWAFISAL
RKNPQQSYVQ LLNSIRDELA TKYSQKPQLS CSHPLDVNLL YVM