MCA1A_NEOFI
ID MCA1A_NEOFI Reviewed; 435 AA.
AC A1D3V4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Metacaspase-1A;
DE EC=3.4.22.-;
DE Flags: Precursor;
GN Name=casA; ORFNames=NFIA_017980;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW23097.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS027688; EAW23097.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001264994.1; XM_001264993.1.
DR AlphaFoldDB; A1D3V4; -.
DR SMR; A1D3V4; -.
DR STRING; 36630.CADNFIAP00001658; -.
DR EnsemblFungi; EAW23097; EAW23097; NFIA_017980.
DR GeneID; 4591316; -.
DR KEGG; nfi:NFIA_017980; -.
DR eggNOG; KOG1546; Eukaryota.
DR OrthoDB; 821819at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR SUPFAM; SSF52129; SSF52129; 1.
PE 3: Inferred from homology;
KW Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW Zymogen.
FT PROPEP 1..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000333656"
FT CHAIN ?..435
FT /note="Metacaspase-1A"
FT /id="PRO_0000333657"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 231
FT /evidence="ECO:0000250"
FT ACT_SITE 287
FT /evidence="ECO:0000250"
SQ SEQUENCE 435 AA; 47607 MW; 35F54A0C76CFD334 CRC64;
MQNHHHQQSS YGGGYPGQAY REQHPPPNPY GYGQPSPQPG YGAPPPHNGY ATAVGIRPAA
ATYWKRGVQW KTAWYVIAFG AGRNASALES VKYAAADTCN TGMNQYQNPY SHGHQGGPPP
PPTDPVAFGH GAPQGYSFQY SRCTGKRKAL LIGINYFGQK GQLRGCINDV KNMSTYLNQN
FGYAREDMVL LTDDQQNPMS QPTKANILRA MHWLVKDAQP NDSLFFHYSG HGGQTPDLDG
DEEDGYDEVI YPVDFRQAGH IVDDEMHRIM VRPLRPGVRL TAIFDSCHSG SALDLPYIYS
TQGILKEPNL AKEAGQGLLG VVSAYARGDM GGMVSTAVGF LKRATKGDEA YTRSKQTKTS
PADVIMWSGS KDSQTSQDAQ IAGQATGAMS WAFITALRKN PQQSYVQLLN SIRDELATKY
SQKPQLSCSH PLGKH
