ID   MCA1A_NEUCR             Reviewed;         454 AA.
AC   Q7S232;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Metacaspase-1A;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casA; ORFNames=NCU09882;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA29413.2; -; Genomic_DNA.
DR   RefSeq; XP_958649.2; XM_953556.3.
DR   AlphaFoldDB; Q7S232; -.
DR   SMR; Q7S232; -.
DR   STRING; 5141.EFNCRP00000009641; -.
DR   PRIDE; Q7S232; -.
DR   EnsemblFungi; EAA29413; EAA29413; NCU09882.
DR   GeneID; 3874804; -.
DR   KEGG; ncr:NCU09882; -.
DR   VEuPathDB; FungiDB:NCU09882; -.
DR   HOGENOM; CLU_029389_0_0_1; -.
DR   InParanoid; Q7S232; -.
DR   OMA; AMIPTRE; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333660"
FT   CHAIN           ?..454
FT                   /note="Metacaspase-1A"
FT                   /id="PRO_0000333661"
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        244
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        300
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   454 AA;  49344 MW;  EFE394489D998E3D CRC64;
     MSYGYPGQGY GPGGGHHQPP PPQWDGQQQH HHQGGYGYSN PGQGQYNPQP PQDQGYGGYH
     QQPPQQYQQG SYNQGQYPPQ GGYGGPYGQQ QQHHQQGHSQ RPPGPPPDGY DIYGYPIGSG
     HQTRNQGSHE IHEIPSGTQQ FGHGAPEGYG FQYSNCSGRR KALLIGINYL GQDAELHGCI
     NDTKNVSAFL VENYGYKRED MVILTDDATN PLLQPTKENI LRAMQWLVAG AQPNDALFLH
     YSGHGGQTKD TDGDEDDGYD EVIYPVDFKT AGHIVDDQIH DTVVKPLQPG VRLTAIFDSC
     HSGSVLDLPY IYSTKGVIKE PNLAKEAGQG LLAAVGSYAR GDIGGMASSL FSVAKTAFGG
     GNEAYERTKR TKTSPADVIM WSGSKDDQTS ADATIASQAT GAMSWAFITA IKANPKQSYV
     QLLNSIRDVL ETKYTQKPQL SSSHPIDVDM LFVM