ID   MCA1B_ASPFU             Reviewed;         408 AA.
AC   Q4WYT0; A1XPL0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Metacaspase-1B;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casB; ORFNames=AFUA_3G14140;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=H237;
RX   PubMed=17176258; DOI=10.1111/j.1365-2958.2006.05534.x;
RA   Richie D.L., Miley M.D., Bhabhra R., Robson G.D., Rhodes J.C., Askew D.S.;
RT   "The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth
RT   under conditions of endoplasmic reticulum stress.";
RL   Mol. Microbiol. 63:591-604(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in cell death (apoptosis) (By similarity). Required
CC       for the apoptotic-like loss of membrane phospholipid asymmetry at
CC       stationary phase and facilitates growth under conditions of endoplasmic
CC       reticulum stress. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL92173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DQ518210; ABF71663.1; -; Genomic_DNA.
DR   EMBL; AAHF01000002; EAL92173.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_754211.1; XM_749118.1.
DR   AlphaFoldDB; Q4WYT0; -.
DR   SMR; Q4WYT0; -.
DR   STRING; 746128.CADAFUBP00003433; -.
DR   GeneID; 3512114; -.
DR   KEGG; afm:AFUA_3G14140; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_2_1; -.
DR   InParanoid; Q4WYT0; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333622"
FT   CHAIN           ?..408
FT                   /note="Metacaspase-1B"
FT                   /id="PRO_0000333623"
FT   REGION          1..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        199
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        255
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   408 AA;  45473 MW;  9443CB353DACB4E5 CRC64;
     MYHRHSAPPP PGWSGGYPPR QQQWPPPQPY EYPPYPPQGP PPAHTFPPPA HRDYPSPYPT
     PPPHSPSPYQ HPHHGHSQSW SVPAVPPRPP LEAQQFGNGA PSHYRFQYSA CTGRRRALLI
     GINYIGQPNQ LRGCINDVTN MSTFLHERYG YRREDMVILT DDQKNPLSIP TKANILRAMQ
     WLVKDAQPND SLFLHFSGHG GRTPDLDGDE EDGYDDVIYP VDYRVAGHIV DDEMHNIMVR
     PLRPGVRLTV IFDSCHSGTA LDLPYVYSTQ GILKEPNLAK EAAQDLFSAI SSYGKGDLSG
     VAMTAIGFLK KAAKGDSARQ RTVMTKTSPA DVVMFSGSKD TQTSADTFQD GEARGALSWA
     FIKSLKQWPN QSYLQLLNSI RAQLDGKYTQ KPQLSCSHPL DVNLLFVM