MCA1B_ASPOR
ID MCA1B_ASPOR Reviewed; 419 AA.
AC Q2UCB7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Metacaspase-1B;
DE EC=3.4.22.-;
DE Flags: Precursor;
GN Name=casB; ORFNames=AO090012000660;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR EMBL; AP007161; BAE60798.1; -; Genomic_DNA.
DR RefSeq; XP_001727637.1; XM_001727585.2.
DR AlphaFoldDB; Q2UCB7; -.
DR SMR; Q2UCB7; -.
DR STRING; 510516.Q2UCB7; -.
DR EnsemblFungi; BAE60798; BAE60798; AO090012000660.
DR GeneID; 5988111; -.
DR KEGG; aor:AO090012000660; -.
DR VEuPathDB; FungiDB:AO090012000660; -.
DR HOGENOM; CLU_029389_0_2_1; -.
DR OMA; PTKANMI; -.
DR Proteomes; UP000006564; Chromosome 4.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR SUPFAM; SSF52129; SSF52129; 1.
PE 3: Inferred from homology;
KW Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW Zymogen.
FT PROPEP 1..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000333630"
FT CHAIN ?..419
FT /note="Metacaspase-1B"
FT /id="PRO_0000333631"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..59
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 210
FT /evidence="ECO:0000250"
FT ACT_SITE 266
FT /evidence="ECO:0000250"
SQ SEQUENCE 419 AA; 46738 MW; 1BDD8B37980C701E CRC64;
MYHPNYNYPP PQPGWGGGYY PPPQQHQQQQ QWSPPPPQPY YSNGYPPPSQ SPHSYSPPQY
PPHGQYEYGH HTPTPPPSSG SQYRSYHSHS PSWGQMPPRP PMEAQQFGKG APSNYRFQYS
ACTGRRKALL IGINYAGQPN ALRGCINDVT NMSTFLHERY GYRREDMVIL TDDQQNPMSV
PTKANILRAM QWLVKDAQRN DSLFIHFSGH GGRTPDLDGD EEDGYDDVIY PVDYRTAGHI
VDDDMHAIMV RPLQPGVRLT AIFDSCHSGT ALDLPYVYST QGILKEPNLA KEAAQDLFSA
ITSYGQGDFA SVAQTAIGFL KKAALGESAR ERTVKTKTSP ADVVMFSGSK DTQTSADTFQ
DGQARGALSW AFIKTLQARP NQSYLQLLNS IRSELEGKYS QKPQLSCSHP LDTNLLFVM
