ID   MCA1B_ASPTN             Reviewed;         378 AA.
AC   Q0CQL9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Metacaspase-1B;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casB; ORFNames=ATEG_04015;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476598; EAU35817.1; -; Genomic_DNA.
DR   RefSeq; XP_001213193.1; XM_001213193.1.
DR   AlphaFoldDB; Q0CQL9; -.
DR   SMR; Q0CQL9; -.
DR   STRING; 341663.Q0CQL9; -.
DR   EnsemblFungi; EAU35817; EAU35817; ATEG_04015.
DR   GeneID; 4318443; -.
DR   VEuPathDB; FungiDB:ATEG_04015; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_3_1_1; -.
DR   OMA; PTKANMI; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333634"
FT   CHAIN           ?..378
FT                   /note="Metacaspase-1B"
FT                   /id="PRO_0000333635"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        225
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   378 AA;  41709 MW;  144E8AD19A6DDC37 CRC64;
     MCSPPPYPPQ GHHYPPSPHG SYYSPTPYGA APSPPQSSSP HPRGYHSPSP SWGQLPPRPP
     QEAQSFGGGA PSNYRFQYSA CTGRRKALLI GINYIGQPNQ LRGCINDVAN VSRYLNERCR
     YRREDMVILT DDQENPLSIP TKNNILRAMQ WLVKDAQPND SLFIHFSGHG GRTPDLDGDE
     EDGYDDVIYP VDYRTAGHIV DDEMHAIMVR PLRPGVRLTA IFDSCHSGTA LDLPYVYSTQ
     GVLKEPNLAK EAAMDLFSAI SSYGQGDLTG MAKTAIGFFK KAAIGDSARQ RTVMTKTSPA
     DVVMFSGSKD TQTSADTFQD GEARGALSWA FVKTLQERPH QSYLQLLNSI RAELEGKYTQ
     KPQLSCSHPL DVNLLFVM