ID   MCA1B_NEOFI             Reviewed;         411 AA.
AC   A1D611;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Metacaspase-1B;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casB; ORFNames=NFIA_063160;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; DS027690; EAW21155.1; -; Genomic_DNA.
DR   RefSeq; XP_001263052.1; XM_001263051.1.
DR   AlphaFoldDB; A1D611; -.
DR   SMR; A1D611; -.
DR   STRING; 36630.CADNFIAP00006412; -.
DR   EnsemblFungi; EAW21155; EAW21155; NFIA_063160.
DR   GeneID; 4589807; -.
DR   KEGG; nfi:NFIA_063160; -.
DR   VEuPathDB; FungiDB:NFIA_063160; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_0_1; -.
DR   OMA; PTKANMI; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333658"
FT   CHAIN           ?..411
FT                   /note="Metacaspase-1B"
FT                   /id="PRO_0000333659"
FT   REGION          1..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..68
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        198
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        254
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   411 AA;  45807 MW;  A6709D3E756EF08F CRC64;
     MYHRHSAPPP PGRSRGYPPP QQQWPPQPYQ YLPYPPQGPP PAHTFPPPAH RSYPSPYPTP
     PPHSPSPYQY PHHGHSQSWS APALPPRPPL EAQQFGNGAP SHYRFQYSAC TGRRRALLIG
     INYIGQPNQL RGCINDVTNM STFLHERYGY RREDMVILTD DQKNPLSIPT KANILRAMQW
     LVKDAQPNDS LFLHFSGHGG RTPDLDGDEE DGYDDVIYPV DYRVAGHIVD DEMHNIMVRP
     LRPGVRLTVI FDSCHSGTAL DLPYVYSTQG ILKEPNLAKE AAQDLFSAIS SYGKGDLSGV
     AMTAIGFLKK AAKGDSARKR TVMTKTSPAD VVMFSGSKDT QTSADTFQDG EARGALSWAF
     IKSLRQWPNQ SYLQLLNSIR AQLEGKYTQK PQLSCSHPLG AWVMRAIEEP A