ID   MCA1_CANAL              Reviewed;         448 AA.
AC   Q5ANA8; A0A1D8PK73; B6C800;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; OrderedLocusNames=CAALFM_C305190CA;
GN   ORFNames=CaO19.13416, CaO19.5995;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ni J., Mi Z., Yin J.;
RT   "Cloning and identification of a caspase-like gene from Candida albicans.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; EF626931; ABV00958.1; -; Genomic_DNA.
DR   EMBL; CP017625; AOW28534.1; -; Genomic_DNA.
DR   RefSeq; XP_723205.1; XM_718112.1.
DR   AlphaFoldDB; Q5ANA8; -.
DR   SMR; Q5ANA8; -.
DR   STRING; 237561.Q5ANA8; -.
DR   PRIDE; Q5ANA8; -.
DR   GeneID; 3635233; -.
DR   KEGG; cal:CAALFM_C305190CA; -.
DR   CGD; CAL0000184470; MCA1.
DR   VEuPathDB; FungiDB:C3_05190C_A; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_1_1; -.
DR   InParanoid; Q5ANA8; -.
DR   OMA; DFRTAGH; -.
DR   OrthoDB; 821819at2759; -.
DR   PHI-base; PHI:6795; -.
DR   PRO; PR:Q5ANA8; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:EnsemblFungi.
DR   GO; GO:0006915; P:apoptotic process; IMP:CGD.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333638"
FT   CHAIN           ?..448
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333639"
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..76
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        231
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        292
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   448 AA;  49199 MW;  F3C69F7E1A2425E7 CRC64;
     MFPGQGRHTY GGQQSNYSNQ QQGYDQGYNQ GYGQAYGQEY NQGYDRPSGP PPGQGQYNRP
     SGPPPGPPPG QGQYNRPSGP PPSQQGQYNR PSGPPPGQYG NNQTRGSGNE QNYGNMHGSG
     HYSRPPTDSQ SFGVENYNYQ YSNCSGRKKA LLIGINYIGT KNELRGPIND VNNVEQFLLA
     NGYSSDNIVK LTDDQRVQRA IPTRQNILDA IQWLVKDARP NDALFFHYSG HGGQTEDQPD
     EYGNYDEDDG YDEVIYPLDF ETNGFIIDDL LHTMMVKTLP QGCRLTALFD SCHSGSVLDL
     PYMYSTKGVL KEPNVMKEAG AGLLQSAMAY ATGDRSRMLS GLGGVVKTFM NQGKAEKANE
     YSKQTNTAPC DAISLSGCKD DQTSADSKEN GTATGAMSYA FLTVMSQNPN QSYLSLLQNM
     REILSAKYSQ KPQLSASHPI DTNLQFIF