ID   MCA1_CANGA              Reviewed;         392 AA.
AC   Q6FPX9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; OrderedLocusNames=CAGL0I10945g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CR380955; CAG60660.1; -; Genomic_DNA.
DR   RefSeq; XP_447715.1; XM_447715.1.
DR   AlphaFoldDB; Q6FPX9; -.
DR   SMR; Q6FPX9; -.
DR   STRING; 5478.XP_447715.1; -.
DR   MEROPS; C14.035; -.
DR   EnsemblFungi; CAG60660; CAG60660; CAGL0I10945g.
DR   GeneID; 2889355; -.
DR   KEGG; cgr:CAGL0I10945g; -.
DR   CGD; CAL0132628; YCA1.
DR   VEuPathDB; FungiDB:CAGL0I10945g; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_3_1_1; -.
DR   InParanoid; Q6FPX9; -.
DR   OMA; NIGAMSH; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:EnsemblFungi.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:EnsemblFungi.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333640"
FT   CHAIN           ?..392
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333641"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        182
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        238
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   392 AA;  43804 MW;  BBFBBF05454BEE01 CRC64;
     MYPGSGNYSY NNRPSMPPPG FNGDGQGYRQ EYGNQYGGGY QQQQYQDQYQ GENRGQYQGQ
     YQDQPEYGRP PSGMVRPPSS IQQGNGQQFQ YSQMTGRRKA LLIGINYIGS KNALRGCIND
     AHNIFNYLTT YCGYRPEDIV MLTDDQREMV KIPLKENIIR AMQWLVKDAQ PNDALFFHYS
     GHGGQTKDLD GDEEDGMDDV IYPVDFESVG PLIDDTMHDI MVKSLPQGAR LTALFDSCHS
     GTVLDLPYTY STKGVIKEPN MWKDVGSDGI QAAMAYATGN RSALFSSIGN MVSSVTKKQN
     VDRERVRQIK FSPADVIMLS GSKDNQTSAD TFADGQNIGA MSHAFISVMT RQPQQSYLSL
     LQNLRNELAG KYSQKPQLSA SHPIDVNLQF IM