ID   MCA1_COCIM              Reviewed;         462 AA.
AC   Q1E0A3; J3KD04;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; ORFNames=CIMG_04010;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; GG704916; EAS32986.3; -; Genomic_DNA.
DR   RefSeq; XP_001244569.1; XM_001244568.2.
DR   AlphaFoldDB; Q1E0A3; -.
DR   SMR; Q1E0A3; -.
DR   STRING; 246410.Q1E0A3; -.
DR   EnsemblFungi; EAS32986; EAS32986; CIMG_04010.
DR   GeneID; 4565012; -.
DR   KEGG; cim:CIMG_04010; -.
DR   VEuPathDB; FungiDB:CIMG_04010; -.
DR   InParanoid; Q1E0A3; -.
DR   OMA; DFRTAGH; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333642"
FT   CHAIN           ?..462
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333643"
FT   REGION          1..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..109
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        253
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        309
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   462 AA;  50389 MW;  FEA80F66CC4F0D14 CRC64;
     MSYYPPPSGY PGGPPAYPPP QQQQQQQQQY PSYGAPPPQY PPQNNYAPPS YPPPGQYGHP
     PQPGYPPHSS PYGHTPSPQP PYGHPPPQHP PHQPPHRPPP SPGYGHLPPS TPNSGPAFHG
     QPGIATVNNN DYVHGNHSAP PPPPSGSVAF GHGAPQGYSY QYSNCTGKRK ALLIGINYFG
     QRGQLRGCIN DVKNMSTYLN QSFNYAREDM VILTDDQQNP MSQPTKANIL RAMHWLVKDA
     RPNDSLFFHY SGHGGQTPDL DGDEDDGYDE VIYPVDFRNA GHIVDDEMHR IMVRPLPAGV
     RLTAIFDSCH SGSALDLPYI YSTQGVLKEP NLAKEAGQGL LGVVSAYARG DMGSMVSTAM
     GFIKKATRGE ETYQRAKQTK TSPADVIMWS GSKDVQTSAD ATINGQATGA LSWAFITALK
     KNPQQSYVQL LNSIRDELAS KYSQKPQLSC SHPLDTNLLY VM