ID   MCA1_CRYNJ              Reviewed;         463 AA.
AC   P0CM58; Q55KQ8; Q5KAR8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; OrderedLocusNames=CNJ00740;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; AE017350; AAW45938.1; -; Genomic_DNA.
DR   RefSeq; XP_567455.1; XM_567455.1.
DR   AlphaFoldDB; P0CM58; -.
DR   SMR; P0CM58; -.
DR   STRING; 5207.AAW45938; -.
DR   PaxDb; P0CM58; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_2_1; -.
DR   InParanoid; P0CM58; -.
DR   OMA; DFRTAGH; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000002149; Chromosome 10.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333644"
FT   CHAIN           ?..463
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333645"
FT   REGION          1..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        247
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        309
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   463 AA;  50236 MW;  19F03AF8291B821A CRC64;
     MSWNQYPGGG HHQQGGYGYR PPPPQWAQQG PPPPPNMGYR PPPPPQAYYN NPPPPQQYQR
     PAPQQNGYQQ GGYQQQQQSQ GNYRTSNGGY VPPTGAPVEA SYHHTGAGYT PPSGTPQRTS
     APYGAGAPIR PPSQAQHYGP QLQGQGGQSA QPYFQYSQCT GKKKALCIGI NYVGSSSALA
     GCINDAHNVQ KFLIERYGYK SEDIVMLTDD ARNPRQIPTR ANILAAMHWL VQGAQPNDSL
     FFHYSGHGGQ TPDLDGDEDD GYDEVIYPLD FKTAGHIVDD DITDCKGRHN IMVRPLPAGC
     RLTAIYDSCH SGTALDLPYI YSTEGVIKEP NLLAEAGQGL LSAGMSYLRG DTGGMLQGIM
     GIGKKVMNQN SGAMEKARQT KTSPADVISW SGCKDSQTSA DTQEAGRATG AMSYAFIAAL
     TKYPQQSYVQ LLNTIRDELK GKYDQKPQLS ASHPMDTNIL FIC