ID   MCA1_DEBHA              Reviewed;         440 AA.
AC   Q6BH13;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; OrderedLocusNames=DEHA2G22176g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG91018.2; -; Genomic_DNA.
DR   RefSeq; XP_462508.2; XM_462508.1.
DR   AlphaFoldDB; Q6BH13; -.
DR   SMR; Q6BH13; -.
DR   STRING; 4959.XP_462508.2; -.
DR   MEROPS; C14.035; -.
DR   EnsemblFungi; CAG91018; CAG91018; DEHA2G22176g.
DR   GeneID; 2905458; -.
DR   KEGG; dha:DEHA2G22176g; -.
DR   VEuPathDB; FungiDB:DEHA2G22176g; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_1_1; -.
DR   InParanoid; Q6BH13; -.
DR   OMA; AMIPTRE; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333646"
FT   CHAIN           ?..440
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333647"
FT   REGION          1..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..59
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        230
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        286
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   440 AA;  47809 MW;  18B00E27079F6D6D CRC64;
     MFPGSGRKTY RQQAPPPGPP NGYQYGPPPG AQGQYPPPQG YPPQGYPPQG YPPQGYAPQG
     YPPQGYAPQG YAPQGYQQQG GQQQGGQQQG GQQQGGQRQT YATQEAQNFG QGVGNPHPTG
     PPPSNPQGFG QNSGMTFQYS NCNGKKKALL VGINYTGSKN QLRGCINDVK NMSNFLNQHF
     GYSYDDMVIL TDDQNQRARI PTKENIIRAM QWLVKDARPN DSLVFHYSGH GGVTKDLVGD
     EESGMDDVIY PLDFEVNGHI IDDIMHDIMV KPLPQGCRLT ALYDSCHSGT ALDLPYVYST
     KGVVKEPNLL KDAGTGAFNA LLSYETGNIS GAISSLSGIV KKISNSASTN RDQVIRMKAS
     PADVISISGC KDDQTSADAR EGGQSTGAMS WSFITTMNQM PNQSYLSLLN NMRTLLKSKY
     SQKPQLSCSH PQDMNLKFIM