ID   MCA1_KLULA              Reviewed;         433 AA.
AC   Q6CLS0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; OrderedLocusNames=KLLA0F00880g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97826.2; -; Genomic_DNA.
DR   RefSeq; XP_455119.2; XM_455119.2.
DR   AlphaFoldDB; Q6CLS0; -.
DR   SMR; Q6CLS0; -.
DR   STRING; 28985.XP_455119.2; -.
DR   EnsemblFungi; CAG97826; CAG97826; KLLA0_F00880g.
DR   GeneID; 2895835; -.
DR   KEGG; kla:KLLA0_F00880g; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_2_1; -.
DR   InParanoid; Q6CLS0; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:EnsemblFungi.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:EnsemblFungi.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333650"
FT   CHAIN           ?..433
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333651"
FT   REGION          1..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        222
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        278
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   433 AA;  48077 MW;  EFC0B8423BA888E8 CRC64;
     MYPGRAKPTY NNQQAQQAQS QVGYQTGYSN AQPQQQYYTA PQQQNVSGSS MSFQHQFYPP
     PNQSPPQYNT GQYARPAAPP PGQQNYRNDI QQNHASGTVN GPSGYQQPQA MYKPPSQVQH
     TGPNNQVAYQ YSQCTGRRKA LLIGINYFGS ANELRGCIND SHNMFNFLTQ RYGYKAEDIV
     MLNDDTTDPV RVPTKANMLR AMQWLVKDAR PNDALFFHYS GHGGQTEDLD GDEEDGMDDV
     IYPVDFQMAG HIVDDDMHAI MVSPLQPGVR LTALFDSCHS GTVLDLPYTY STKGVIKEPN
     MWKDVGSSGL QAAMAYATGN TTSLVSSLGN VFTTITKSNN NVDRERVKQI KFSPADVIMF
     SGSKDNQTSA DATENGQNTG AMSWAFLTVL SKQPQQSYLS LLQNMRAELS SKYTQKPQLS
     CSHEIDTNLQ FLL