ID   MCA1_MAGO7              Reviewed;         396 AA.
AC   A4QTY2; G4N354;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; ORFNames=MGG_04926;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CM001233; EHA52610.1; -; Genomic_DNA.
DR   RefSeq; XP_003712417.1; XM_003712369.1.
DR   AlphaFoldDB; A4QTY2; -.
DR   SMR; A4QTY2; -.
DR   STRING; 318829.MGG_04926T0; -.
DR   MEROPS; C14.035; -.
DR   EnsemblFungi; MGG_04926T0; MGG_04926T0; MGG_04926.
DR   GeneID; 2675545; -.
DR   KEGG; mgr:MGG_04926; -.
DR   VEuPathDB; FungiDB:MGG_04926; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_2_1; -.
DR   InParanoid; A4QTY2; -.
DR   OMA; GMQQFGH; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333654"
FT   CHAIN           ?..396
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333655"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..50
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        186
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        242
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   396 AA;  43531 MW;  0E321F73920CB1B7 CRC64;
     MSGYPGQGYQ GQGYGQGYGQ GYPPQGGYYP PQPGYGGYPP QPPPPQHYQY GPPQGGYQYP
     PQDGSRAGPS DQAHQPPQGM QQFGHGAPSD YAFQYSQCTG KRKALLIGIN YFGQEGELRG
     CINDVRNLSN FLMEFYQYRR EDMVLLTDDA QDPMSQPTRD NIVRAMHWLV EGAQPNDSLF
     FHYSGHGGQT EDLDGDEDDG YDEVIYPVDF RANGHIVDDD MHLWMVQPLQ AGVRLTAIFD
     SCHSGTALDL PYVYSTSGVL KEPNLAKEAG VGLLGAVQSY ARGDLGGVAT SLFGFAKKAF
     SDKQARDRTM RTKTSPADVI SWSGSKDDQT SADATIASQA TGAMSYAFVS ALRANRNQTY
     NQLLNSIRDI LEGQYSQKPQ LSCSHPLDTE NVWFVM