ID   MCA1_PICGU              Reviewed;         410 AA.
AC   A5D9W7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; ORFNames=PGUG_00072;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK35974.2; -; Genomic_DNA.
DR   RefSeq; XP_001486695.1; XM_001486645.1.
DR   AlphaFoldDB; A5D9W7; -.
DR   SMR; A5D9W7; -.
DR   STRING; 4929.XP_001486695.1; -.
DR   EnsemblFungi; EDK35974; EDK35974; PGUG_00072.
DR   GeneID; 5128747; -.
DR   KEGG; pgu:PGUG_00072; -.
DR   VEuPathDB; FungiDB:PGUG_00072; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_2_1; -.
DR   InParanoid; A5D9W7; -.
DR   OMA; PTKANMI; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333664"
FT   CHAIN           ?..410
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333665"
FT   REGION          1..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        200
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        256
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   410 AA;  45081 MW;  CFDD68AAE0D7E101 CRC64;
     MFPGSGRQTY QQQGYPPPQG APQYNYGPPQ GPPQGYYNGP PQGYNGPPQG PPPQNYNYGH
     YGPPQGQGQG YGQGGPAPQM YNNNRQSGAM NDVSTAPQRF GNTDMTYQLS NCSGRKKALL
     VGINYFGSSN ELRGCVNDIK NMSNFLNRRF GYSYDDMVIL TDDQNQRNKI PTKENIIRAM
     QWLVKDARPN DSLVFHYSGH GGITKDLDGD EDEGYDEVIY PVDFQQAGHI VDDDMHAIMV
     RPLPPGCKLT ALFDSCHSGT ALDLPFVYST KGVVKEPNLW KDAGTDAFGA FMQYERGNIG
     GAISSIGGLL KKVTNSSSSN RQQVINIKAS PADVISISGC KDDQTSADAS INNNATGAMS
     WAFIKTMTDM PEQSYLSLLN NMRTLLKEKY SQKPQLSSSH PQDMNIRFIM