MCA1_SCHPO
ID MCA1_SCHPO Reviewed; 425 AA.
AC O74477;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Metacaspase-1;
DE EC=3.4.22.-;
DE Flags: Precursor;
GN Name=pca1; Synonyms=mca1; ORFNames=SPCC1840.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11090634; DOI=10.1016/s1097-2765(00)00094-0;
RA Uren A.G., O'Rourke K., Aravind L., Pisabarro M.T., Seshagiri S.,
RA Koonin E.V., Dixit V.M.;
RT "Identification of paracaspases and metacaspases. Two ancient families of
RT caspase-like proteins, one of which plays a key role in MALT lymphoma.";
RL Mol. Cell 6:961-967(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RX PubMed=17898859; DOI=10.1139/w07-067;
RA Lim H.-W., Kim S.-J., Park E.-H., Lim C.-J.;
RT "Overexpression of a metacaspase gene stimulates cell growth and stress
RT response in Schizosaccharomyces pombe.";
RL Can. J. Microbiol. 53:1016-1023(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- INDUCTION: Induced by stress-inducing agents such as H(2)O(2), sodium
CC nitroprusside and cadmium chloride. {ECO:0000269|PubMed:17898859}.
CC -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR EMBL; AF316601; AAG38593.1; -; mRNA.
DR EMBL; DQ078253; AAY82367.1; -; Genomic_DNA.
DR EMBL; CU329672; CAA20127.1; -; Genomic_DNA.
DR PIR; T41172; T41172.
DR RefSeq; NP_588503.1; NM_001023493.2.
DR AlphaFoldDB; O74477; -.
DR SMR; O74477; -.
DR BioGRID; 275550; 56.
DR STRING; 4896.SPCC1840.04.1; -.
DR MEROPS; C14.035; -.
DR MaxQB; O74477; -.
DR PaxDb; O74477; -.
DR EnsemblFungi; SPCC1840.04.1; SPCC1840.04.1:pep; SPCC1840.04.
DR GeneID; 2538976; -.
DR KEGG; spo:SPCC1840.04; -.
DR PomBase; SPCC1840.04; pca1.
DR VEuPathDB; FungiDB:SPCC1840.04; -.
DR eggNOG; KOG1546; Eukaryota.
DR HOGENOM; CLU_029389_1_0_1; -.
DR InParanoid; O74477; -.
DR OMA; AMIPTRE; -.
DR PhylomeDB; O74477; -.
DR PRO; PR:O74477; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IMP:PomBase.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; NAS:PomBase.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR SUPFAM; SSF52129; SSF52129; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Hydrolase; Nucleus; Protease; Reference proteome;
KW Thiol protease; Zymogen.
FT PROPEP 1..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000333668"
FT CHAIN ?..425
FT /note="Metacaspase-1"
FT /id="PRO_0000310335"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 214
FT /evidence="ECO:0000250"
FT ACT_SITE 270
FT /evidence="ECO:0000250"
SQ SEQUENCE 425 AA; 46627 MW; 180191A6B4DBF227 CRC64;
MSYNSNPYNG GQYPPYNTYT RPNYSPNNGS QSNNTVHQYQ PPRMPPPSTR PQTDGNSNQI
PMENVGHISL SSANSHAYAP PSGPPPNTGA NSYGNPNYSG PQLPNTQTQS YNLAGGGNFQ
YQYSTCQGKR KALLIGINYL NTQNELQGCI NDVMSMSQLL IQRYGYKQED MVIMTDTASN
QRAIPTRQNM LDAMRWLVSD AQPNDALFFH YSGHGGQTKD LDGDEVDGYD ETIYPLDHQY
AGQIIDDEMH EIMVKPLPAG CRLTALFDSC HSGGALDLPF TYSTKGVLKE PNMLKESGMD
VLHAGLSYAS GDIMGAINNV KNIFTSATNG FNNNALQYSR QVKFSPADVI SLSGCKDNQT
SADTSVNGFA TGALSYAFRE VVTQNPQLSY LQLLRGIRQV LSNKYSQLPQ LSCSHPLDMN
LAMVL
