ID   MCA1_SCLS1              Reviewed;         432 AA.
AC   A7F075;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=casA; ORFNames=SS1G_10992;
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CH476637; EDN95117.1; -; Genomic_DNA.
DR   RefSeq; XP_001587752.1; XM_001587702.1.
DR   AlphaFoldDB; A7F075; -.
DR   SMR; A7F075; -.
DR   STRING; 665079.A7F075; -.
DR   EnsemblFungi; EDN95117; EDN95117; SS1G_10992.
DR   GeneID; 5483933; -.
DR   KEGG; ssl:SS1G_10992; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_0_2_1; -.
DR   InParanoid; A7F075; -.
DR   OMA; DFRTAGH; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333669"
FT   CHAIN           ?..432
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333670"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          41..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        223
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        279
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   432 AA;  47735 MW;  6938217E65BB7048 CRC64;
     MEVMDHHHHT SSTRPNPTTR RMNFFLPNAI HMDSHLLYYR PQPGYGAPPP QGGYGYPQPP
     PPQQPYGYSQ PPPQQYGGYN GVPPNAPQYG RPGMPSVNSN AYINGNQNAP PPPPQGMHSF
     GQGAPQNYAF QYSNCTGRRK ALLIGINYFG QRGQLRGCIN DVKNMSSYLH ENFGYQRDDM
     VILTDDQQNP MSQPTKQNIL RAMHWLVKDA RPNDSLFFHY SGHGGQTKDL DGDEEDGYDE
     VIYPVDFRQV GHIVDDEMHR IMVQPLQPGV RLTAIFDSCH SGTALDLPYV YSTQGVLKEP
     NLAKEAGQGL LGVISSYSQG DMSGVASNLM GFFKKATTGD DAYNKTLATK TSPADVVMWS
     GSKDDQTSAD ATIAAQATGA MSWAFITAMK KNPQQSYVQL LNSIRDELAT KYTQKPQLSC
     SHPLSMVPPL LL