ID   MCA1_USTMA              Reviewed;         402 AA.
AC   Q4PEQ5; A0A0D1CZ33;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; ORFNames=UMAG_01408;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CM003141; KIS71513.1; -; Genomic_DNA.
DR   RefSeq; XP_011387285.1; XM_011388983.1.
DR   AlphaFoldDB; Q4PEQ5; -.
DR   SMR; Q4PEQ5; -.
DR   STRING; 5270.UM01408P0; -.
DR   EnsemblFungi; KIS71513; KIS71513; UMAG_01408.
DR   GeneID; 23562441; -.
DR   KEGG; uma:UMAG_01408; -.
DR   VEuPathDB; FungiDB:UMAG_01408; -.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_3_1_1; -.
DR   InParanoid; Q4PEQ5; -.
DR   OMA; DFRTAGH; -.
DR   OrthoDB; 821819at2759; -.
DR   Proteomes; UP000000561; Chromosome 2.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333671"
FT   CHAIN           ?..402
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333672"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        193
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        249
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   402 AA;  42830 MW;  DFD535955846788E CRC64;
     MAYPGQGGHH YQSTHGGGGG GFPAPHGYAQ PGYGYAPPSG PPQGYQSGGG YAPPMQPPPG
     GVQGQMGYGF APPSGPIGPP EYATNHVNYN PQGGMIGNQR YEYSSMQGKR KALLIGINYF
     GQNGELRGCI NDVRNVQNFL RQRGYKDDDM VVLTDDQRDA RSIPTRQNMT AAMHWLVRGA
     QPGDALFFHY SGHGGQAKAT QGDEADGYNE TIIPLDYQQA GQIEDDELHA IMVRPLPVGC
     RLTAIFDSCH SGTALDLPYV YTTSGNVKEP NVIAGVGKGI MGAAMNYARG DVLGMAKGLF
     STFTTAKNTS GAEEVTKQTR SSGADVVMLS GCKDSQTSAD ATEAGKATGA CSFAFLSVMN
     QYPQLTYKQM LNAVRDVLAS KYSQKPQLSS SHPIDMDLLF VV