ID   MCA1_YARLI              Reviewed;         461 AA.
AC   Q6C2Y6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Metacaspase-1;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=MCA1; OrderedLocusNames=YALI0F04059g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG77783.1; -; Genomic_DNA.
DR   RefSeq; XP_504976.1; XM_504976.1.
DR   AlphaFoldDB; Q6C2Y6; -.
DR   SMR; Q6C2Y6; -.
DR   STRING; 4952.CAG77783; -.
DR   EnsemblFungi; CAG77783; CAG77783; YALI0_F04059g.
DR   GeneID; 2907712; -.
DR   KEGG; yli:YALI0F04059g; -.
DR   VEuPathDB; FungiDB:YALI0_F04059g; -.
DR   HOGENOM; CLU_029389_0_1_1; -.
DR   InParanoid; Q6C2Y6; -.
DR   OMA; DFRTAGH; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:EnsemblFungi.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:EnsemblFungi.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Protease; Reference proteome; Thiol protease;
KW   Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000333673"
FT   CHAIN           ?..461
FT                   /note="Metacaspase-1"
FT                   /id="PRO_0000333674"
FT   REGION          1..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..99
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        252
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        308
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   461 AA;  47550 MW;  7DF9E3001A072619 CRC64;
     MSYPGQGGNT YGGGPPGGYG GYNQQDRYGG GGGNYGPPQG PPPGQYGGGY GGPGGGYGGS
     GGGYGPPQGP PPGQYGGSGG PGGYGPPQGP PPGQRGNYGP PQGPPGGQGG GGGGYGHPGM
     GNQAPPGQYG QPGPPGPHGN HNMPPQGNQA FGGTQGYHFQ YSNCSGKKKA LLIGCNYIGS
     KNALRGCIND VHNLQRYLVQ RAGYKPDDMV ILTDDQRDQR SIPTKQNILQ ACQWLVKGAQ
     PNDSLVFHFS GHGGQEKDVD GDEDDGYDEC IYPVDFQRAG SIIDDVLHDI LVKSLPPGCR
     LTALFDSCHS GTALDLPYVY STKGILKEPN LAKEAGQGLL GAVSSYARGD IGGALSSIMG
     TVKQATTGSG ANQRAKQTKT APCDAISISG CKDSQTSADA MEGGTATGAM SFAFIEVMTR
     DPNQSYLSLL NNMREVLRGK YSQKPQLSAS HPTDVNLKFI M