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MCA3_ARATH
ID   MCA3_ARATH              Reviewed;         362 AA.
AC   Q9FMG1; O82525; Q6XPT9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Metacaspase-3;
DE            Short=AtMC3;
DE            EC=3.4.22.-;
DE   AltName: Full=Metacaspase 1a;
DE            Short=AtMCP1a;
GN   Name=AMC3; Synonyms=MCP1A; OrderedLocusNames=At5g64240; ORFNames=MSJ1.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15326173; DOI=10.1074/jbc.m406329200;
RA   Vercammen D., van de Cotte B., De Jaeger G., Eeckhout D., Casteels P.,
RA   Vandepoele K., Vandenberghe I., van Beeumen J., Inze D., van Breusegem F.;
RT   "Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave
RT   substrates after arginine and lysine.";
RL   J. Biol. Chem. 279:45329-45336(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RA   Olney M.A., Briggs W.R.;
RT   "Arabidopsis thaliana mRNA of unknown function.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ikeda Y., Krishnamurthy N., Chua N.-H.;
RT   "Characterization of metacaspases.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA   Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT   features of the regions of 1,191,918 bp covered by seventeen physically
RT   assigned P1 clones.";
RL   DNA Res. 4:401-414(1997).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   GENE FAMILY.
RX   PubMed=20565583; DOI=10.1111/j.1364-3703.2004.00206.x;
RA   Watanabe N., Lam E.;
RT   "Recent advance in the study of caspase-like proteases and Bax inhibitor-1
RT   in plants: their possible roles as regulator of programmed cell death.";
RL   Mol. Plant Pathol. 5:65-70(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9FMG1-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD11574.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY219828; AAP44516.1; -; mRNA.
DR   EMBL; AF087435; AAD11574.1; ALT_FRAME; mRNA.
DR   EMBL; AY322527; AAP84708.1; -; mRNA.
DR   EMBL; AB008268; BAB09855.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97860.1; -; Genomic_DNA.
DR   EMBL; BT002395; AAO00755.1; -; mRNA.
DR   EMBL; BT010372; AAQ56815.1; -; mRNA.
DR   EMBL; AY086951; AAM64514.1; -; mRNA.
DR   PIR; T51728; T51728.
DR   RefSeq; NP_201229.1; NM_125820.3. [Q9FMG1-1]
DR   AlphaFoldDB; Q9FMG1; -.
DR   SMR; Q9FMG1; -.
DR   STRING; 3702.AT5G64240.2; -.
DR   MEROPS; C14.A05; -.
DR   PaxDb; Q9FMG1; -.
DR   PRIDE; Q9FMG1; -.
DR   ProteomicsDB; 239044; -. [Q9FMG1-1]
DR   EnsemblPlants; AT5G64240.2; AT5G64240.2; AT5G64240. [Q9FMG1-1]
DR   GeneID; 836545; -.
DR   Gramene; AT5G64240.2; AT5G64240.2; AT5G64240. [Q9FMG1-1]
DR   KEGG; ath:AT5G64240; -.
DR   Araport; AT5G64240; -.
DR   TAIR; locus:2173398; AT5G64240.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_2_2_1; -.
DR   InParanoid; Q9FMG1; -.
DR   OMA; FNVYEEQ; -.
DR   OrthoDB; 821819at2759; -.
DR   PhylomeDB; Q9FMG1; -.
DR   PRO; PR:Q9FMG1; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FMG1; baseline and differential.
DR   Genevisible; Q9FMG1; AT.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033180; Metacaspase_type_1_plant.
DR   PANTHER; PTHR48104:SF1; PTHR48104:SF1; 1.
DR   SUPFAM; SSF52129; SSF52129; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hydrolase; Protease; Reference proteome;
KW   Thiol protease.
FT   CHAIN           1..362
FT                   /note="Metacaspase-3"
FT                   /id="PRO_0000334601"
FT   ACT_SITE        174
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        230
FT                   /evidence="ECO:0000250"
FT   CONFLICT        151
FT                   /note="R -> K (in Ref. 1; AAP44516)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        157..158
FT                   /note="LV -> VI (in Ref. 1; AAP44516)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        177
FT                   /note="Q -> E (in Ref. 1; AAP44516)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   362 AA;  40480 MW;  DD65B852CB4A91F7 CRC64;
     MASRREVRCR CGRRMWVQPD ARTVQCSTCH TVTQLYSLVD IARGANRIIH GFQQLLRQHQ
     PQHHEQQQQQ MMAQPPPRLL EPLPSPFGKK RAVLCGVNYK GKSYSLKGCI SDAKSMRSLL
     VQQMGFPIDS ILMLTEDEAS PQRIPTKRNI RKAMRWLVEG NRARDSLVFH FSGHGSQQND
     YNGDEIDGQD EALCPLDHET EGKIIDDEIN RILVRPLVHG AKLHAVIDAC NSGTVLDLPF
     ICRMERNGSY EWEDHRSVRA YKGTDGGAAF CFSACDDDES SGYTPVFTGK NTGAMTYSFI
     KAVKTAGPAP TYGHLLNLMC SAIREAQSRL AFNGDYTSSD ASAEPLLTSS EEFDVYATKF
     VL
 
 
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