ID   MCA6_ARATH              Reviewed;         368 AA.
AC   O64519;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Metacaspase-6;
DE            Short=AtMC6;
DE            EC=3.4.22.-;
DE   AltName: Full=Metacaspase 2c;
DE            Short=AtMCP2c;
DE   AltName: Full=Metacaspase-5;
GN   Name=AMC6; Synonyms=AMC5, MCP2C; OrderedLocusNames=At1g79320;
GN   ORFNames=YUP8H12R.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AUTOCATALYTIC CLEAVAGE, GENE FAMILY, AND
RP   NOMENCLATURE.
RX   PubMed=15326173; DOI=10.1074/jbc.m406329200;
RA   Vercammen D., van de Cotte B., De Jaeger G., Eeckhout D., Casteels P.,
RA   Vandepoele K., Vandenberghe I., van Beeumen J., Inze D., van Breusegem F.;
RT   "Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave
RT   substrates after arginine and lysine.";
RL   J. Biol. Chem. 279:45329-45336(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ikeda Y., Krishnamurthy N., Chua N.-H.;
RT   "Characterization of metacaspases.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY.
RX   PubMed=20565583; DOI=10.1111/j.1364-3703.2004.00206.x;
RA   Watanabe N., Lam E.;
RT   "Recent advance in the study of caspase-like proteases and Bax inhibitor-1
RT   in plants: their possible roles as regulator of programmed cell death.";
RL   Mol. Plant Pathol. 5:65-70(2004).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=21395887; DOI=10.1111/j.1365-313x.2011.04554.x;
RA   Watanabe N., Lam E.;
RT   "Arabidopsis metacaspase 2d is a positive mediator of cell death induced
RT   during biotic and abiotic stresses.";
RL   Plant J. 66:969-982(2011).
CC   -!- TISSUE SPECIFICITY: Expressed in roots and flower buds.
CC       {ECO:0000269|PubMed:21395887}.
CC   -!- PTM: Proteolytically processed; by an autocatalytic mechanism.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family. {ECO:0000305}.
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DR   EMBL; AY219831; AAP44519.1; -; mRNA.
DR   EMBL; AY322532; AAP84713.1; -; mRNA.
DR   EMBL; AC002986; AAC17078.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE36230.1; -; Genomic_DNA.
DR   EMBL; BT029232; ABJ98564.1; -; mRNA.
DR   PIR; T01023; T01023.
DR   RefSeq; NP_178050.1; NM_106580.2.
DR   AlphaFoldDB; O64519; -.
DR   SMR; O64519; -.
DR   STRING; 3702.AT1G79320.1; -.
DR   MEROPS; C14.A01; -.
DR   PaxDb; O64519; -.
DR   PRIDE; O64519; -.
DR   ProteomicsDB; 238285; -.
DR   EnsemblPlants; AT1G79320.1; AT1G79320.1; AT1G79320.
DR   GeneID; 844270; -.
DR   Gramene; AT1G79320.1; AT1G79320.1; AT1G79320.
DR   KEGG; ath:AT1G79320; -.
DR   Araport; AT1G79320; -.
DR   TAIR; locus:2207440; AT1G79320.
DR   eggNOG; KOG1546; Eukaryota.
DR   HOGENOM; CLU_029389_4_1_1; -.
DR   InParanoid; O64519; -.
DR   OMA; DAHVKNR; -.
DR   OrthoDB; 792090at2759; -.
DR   PhylomeDB; O64519; -.
DR   PRO; PR:O64519; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; O64519; baseline and differential.
DR   Genevisible; O64519; AT.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Autocatalytic cleavage; Hydrolase; Protease; Reference proteome;
KW   S-nitrosylation; Thiol protease.
FT   CHAIN           1..368
FT                   /note="Metacaspase-6"
FT                   /id="PRO_0000334604"
FT   REGION          153..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        86
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        139
FT                   /evidence="ECO:0000250"
FT   MOD_RES         139
FT                   /note="S-nitrosocysteine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9FYE1"
SQ   SEQUENCE   368 AA;  40242 MW;  0805E526F9420D33 CRC64;
     MAKKALLIGI NYVGTKAELR GCVNDVRRMR ISLVERYGFS EENIKMLIDT DSSSIKPTGK
     NIRQALLDLV EPAKSGDVLF VHYSGHGTRL PAETGEDDDT GYDECIVPSD MNLITDDDFR
     DLVDMVPKDC PITIISDSCH SGGLIDEAKE QIGESTKKKK DSGDSSTINK ETEAEIIEVG
     NRSLPLETLI DMLKQETGND DIEVGKIRTT LFDMFGDDSS PKVKKFMNVI LSNLQETTTT
     IQTVSDEVLG SVENLAQEFL EQKLSDDVKP AIQDVYAGAI NGALPDNGIL ISGCQTDQTS
     SDASPPGHPE LAYGALTNAI QIIIGETKGK ISNKDLVLKA RKLLRKQGFD QRPGLYCNDA
     YVNARFIC