ID   ARGP_VIBCM              Reviewed;         298 AA.
AC   C3LRZ9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=HTH-type transcriptional regulator ArgP {ECO:0000255|HAMAP-Rule:MF_00513};
GN   Name=argP {ECO:0000255|HAMAP-Rule:MF_00513}; Synonyms=iciA;
GN   OrderedLocusNames=VCM66_0467;
OS   Vibrio cholerae serotype O1 (strain M66-2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=579112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M66-2;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Controls the transcription of genes involved in arginine and
CC       lysine metabolism. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP001233; ACP04792.1; -; Genomic_DNA.
DR   RefSeq; WP_001214483.1; NC_012578.1.
DR   AlphaFoldDB; C3LRZ9; -.
DR   SMR; C3LRZ9; -.
DR   PRIDE; C3LRZ9; -.
DR   EnsemblBacteria; ACP04792; ACP04792; VCM66_0467.
DR   GeneID; 57739227; -.
DR   KEGG; vcm:VCM66_0467; -.
DR   HOGENOM; CLU_063829_0_0_6; -.
DR   OMA; QQWKLDS; -.
DR   Proteomes; UP000001217; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00513; HTH_type_ArgP; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR023490; ArgP_Gammaproteobact.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..298
FT                   /note="HTH-type transcriptional regulator ArgP"
FT                   /id="PRO_1000146110"
FT   DOMAIN          4..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
SQ   SEQUENCE   298 AA;  33653 MW;  C7776C56A9FD2521 CRC64;
     MRGLDYRWIE ALDSVVSKGS FERAAEQLFI SQSAVSQRIK QLEKYLAQPV LIREQPPRPT
     LVGKKLLGLY RRVCLIEQEL VPELTNQEHV RPVSMSIATN ADSLATWLLP ALDKVMKSRQ
     VELNLVIYGE SRTLDKLKNG EVVGAISLEP QPITGCSAEY LGQMEYLCVA SPEFYQKYFA
     KGVTPRSLIK APAVSYDQYD ELHNKFLWDY FAVPRDKVIN HTVGSSEAFV RLALSGAAYC
     LIPRLQIISE LESGALINMT PDFMLSYPIF WHHWQLETGV LLEISEAITA YAKSVLPQ