MCBA_ECOLI
ID MCBA_ECOLI Reviewed; 86 AA.
AC P0AAX6; P75781;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Uncharacterized protein McbA;
DE AltName: Full=MqsR-controlled colanic acid and biofilm protein A;
DE Flags: Precursor;
GN Name=mcbA; Synonyms=ybiM; OrderedLocusNames=b0806, JW5106;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, AND REGULATION BY MCBR.
RC STRAIN=K12;
RX PubMed=18309357; DOI=10.1038/ismej.2008.24;
RA Zhang X.-S., Garcia-Contreras R., Wood T.K.;
RT "Escherichia coli transcription factor YncC (McbR) regulates colanic acid
RT and biofilm formation by repressing expression of periplasmic protein YbiM
RT (McbA).";
RL ISME J. 2:615-631(2008).
CC -!- FUNCTION: Affects biofilm formation and mucoidy.
CC {ECO:0000269|PubMed:18309357}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- INDUCTION: Repressed by McbR.
CC -!- SIMILARITY: Belongs to the BhsA/McbA family. {ECO:0000305}.
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DR EMBL; U00096; AAC73893.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA35472.2; -; Genomic_DNA.
DR PIR; F64817; F64817.
DR RefSeq; NP_415327.2; NC_000913.3.
DR RefSeq; WP_000710619.1; NZ_STEB01000019.1.
DR AlphaFoldDB; P0AAX6; -.
DR BioGRID; 4263330; 7.
DR STRING; 511145.b0806; -.
DR PaxDb; P0AAX6; -.
DR PRIDE; P0AAX6; -.
DR EnsemblBacteria; AAC73893; AAC73893; b0806.
DR EnsemblBacteria; BAA35472; BAA35472; BAA35472.
DR GeneID; 66670922; -.
DR GeneID; 947523; -.
DR KEGG; ecj:JW5106; -.
DR KEGG; eco:b0806; -.
DR PATRIC; fig|1411691.4.peg.1472; -.
DR EchoBASE; EB3102; -.
DR eggNOG; ENOG503333J; Bacteria.
DR HOGENOM; CLU_158602_2_1_6; -.
DR OMA; DKAHRQG; -.
DR PhylomeDB; P0AAX6; -.
DR BioCyc; EcoCyc:G6415-MON; -.
DR PRO; PR:P0AAX6; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0009242; P:colanic acid biosynthetic process; IMP:EcoCyc.
DR Gene3D; 3.30.1660.10; -; 1.
DR InterPro; IPR025543; Dodecin-like.
DR InterPro; IPR036275; YdgH-like_sf.
DR InterPro; IPR010854; YdgH/BhsA/McbA-like_dom.
DR Pfam; PF07338; DUF1471; 1.
DR SUPFAM; SSF159871; SSF159871; 1.
PE 2: Evidence at transcript level;
KW Periplasm; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..86
FT /note="Uncharacterized protein McbA"
FT /id="PRO_0000168725"
SQ SEQUENCE 86 AA; 8896 MW; 8E958A6476A63307 CRC64;
MKKCLTLLIA TVLSGISLTA YAAQPMSNLD SGQLRPAGTV SATGASNLSD LEDKLAEKAR
EQGAKGYVIN SAGGNDQMFG TATIYK
