ID   MCBF_ECOLX              Reviewed;         247 AA.
AC   P05529;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein McbF;
GN   Name=mcbF;
OS   Escherichia coli.
OG   Plasmid IncFII pMccB17.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3049078; DOI=10.1002/j.1460-2075.1988.tb03018.x;
RA   Garrido M.D.C., Herrero M., Kolter R., Moreno F.;
RT   "The export of the DNA replication inhibitor microcin B17 provides immunity
RT   for the host cell.";
RL   EMBO J. 7:1853-1862(1988).
CC   -!- FUNCTION: Together with two further proteins McbE and McbG this protein
CC       causes immunity to the peptide antibiotic microcin B17, which inhibits
CC       DNA replication in enterobacteriaceae. Immunity is determined by two
CC       different mechanisms. McbE is involved in the production of
CC       extracellular MccB17 and, in a complex with mcbf it also serves as
CC       'pump' for the export of active MccB17 from the cytoplasm to the
CC       periplasmic space.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X07875; CAA30723.1; -; Genomic_DNA.
DR   PIR; S01228; BVECMF.
DR   AlphaFoldDB; P05529; -.
DR   SMR; P05529; -.
DR   TCDB; 3.A.1.116.1; the atp-binding cassette (abc) superfamily.
DR   BioCyc; MetaCyc:MON-21090; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; ATP-binding; Nucleotide-binding; Plasmid; Transport.
FT   CHAIN           1..247
FT                   /note="Protein McbF"
FT                   /id="PRO_0000092489"
FT   DOMAIN          6..234
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         40..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   247 AA;  28819 MW;  3A7F5235F3696E71 CRC64;
     MTIPLLEINS LSFSYKVNLP PVFNNLSLKI EQGELIGLLG ENPAGKTTLF NLIRGGVSNY
     EGTLKRNFSG GELVSLPQVI NLSGTLRNEE VLDLICCFNK LTKKQAWTDV NHKWNDNFFI
     RYDKIRRKRT YTVSYGEKRW LIISLMVTLC KNARLFLLDE PTVGIDIQYR MMLWELINKI
     TADGKTVFFS THIFDELTRD KIPFYMLSKN SINRYSDMSD FIQSNNETTQ KRHLLKKLWE
     QETDTWI