60A_DROVI
ID 60A_DROVI Reviewed; 436 AA.
AC Q24735;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Protein 60A;
DE AltName: Full=Protein glass bottom boat;
DE Flags: Precursor;
GN Name=gbb; Synonyms=60A, TGFb-60A;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8688461; DOI=10.1016/0167-4781(96)00080-2;
RA Du W., Doctor J.S.;
RT "Isolation and sequence of the Drosophila virilis 60 A gene, a transforming
RT growth factor-beta superfamily member related to vertebrate bone
RT morphogenetic proteins.";
RL Biochim. Biophys. Acta 1307:273-279(1996).
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; U48595; AAC47262.1; -; Genomic_DNA.
DR AlphaFoldDB; Q24735; -.
DR SMR; Q24735; -.
DR STRING; 7244.FBpp0236284; -.
DR PRIDE; Q24735; -.
DR eggNOG; KOG3900; Eukaryota.
DR ChiTaRS; Gbeta13F; fly.
DR GO; GO:0031045; C:dense core granule; IEA:EnsemblMetazoa.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR GO; GO:0007504; P:larval fat body development; IEA:EnsemblMetazoa.
DR GO; GO:0099558; P:maintenance of synapse structure; IEA:EnsemblMetazoa.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:EnsemblMetazoa.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:0030707; P:ovarian follicle cell development; IEA:EnsemblMetazoa.
DR GO; GO:0048636; P:positive regulation of muscle organ development; IEA:EnsemblMetazoa.
DR GO; GO:0045887; P:positive regulation of synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0046928; P:regulation of neurotransmitter secretion; IEA:EnsemblMetazoa.
DR GO; GO:2000736; P:regulation of stem cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0098917; P:retrograde trans-synaptic signaling; IEA:EnsemblMetazoa.
DR GO; GO:0035222; P:wing disc pattern formation; IEA:EnsemblMetazoa.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..317
FT /evidence="ECO:0000255"
FT /id="PRO_0000033662"
FT CHAIN 318..436
FT /note="Protein 60A"
FT /id="PRO_0000033663"
FT REGION 293..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 377
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 335..401
FT /evidence="ECO:0000250"
FT DISULFID 364..433
FT /evidence="ECO:0000250"
FT DISULFID 368..435
FT /evidence="ECO:0000250"
FT DISULFID 400
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 436 AA; 49999 MW; C744B4AE58796692 CRC64;
MTASLVVLPS LWLILIIFTA PYTHCTQSGI YIDNGKDQTV MERVLTDDDK LDVSHEILEF
LGIAARPLHH KSHGLSLRKS APKFLLDVYY RITAEEGLAI KNKSDHSRSK RDANESEQNF
ITDLDKRAID ESDIIMTFLN KRNHNVEEMR HEHGRRLWFD VNNIPTDNYL MMAELRIYQN
SNEGKWTTTN KQFTVTVYML RSGGSAPNML EPLSSVNTTG DYVGWLELNV TEALHDWRVN
SNENHGIYIG AHALNKPERE IKLDDIGLIH RRTKVDDENQ PFMIGFFRGP ELIKSTSGHS
TQKRTKRSTL HQRKKSKSEP VNPFIENSIE NTRSCQMQTL YIDFKDLGWH DWIIAPEGYG
AFYCSGECNF PLNAHMNATN HAIVQTLVHL LEPKRVPKPC CAPTRLGALP VLYHLNDENV
NLKKYRNMIV KSCGCH