ID   60A_DROVI               Reviewed;         436 AA.
AC   Q24735;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein 60A;
DE   AltName: Full=Protein glass bottom boat;
DE   Flags: Precursor;
GN   Name=gbb; Synonyms=60A, TGFb-60A;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8688461; DOI=10.1016/0167-4781(96)00080-2;
RA   Du W., Doctor J.S.;
RT   "Isolation and sequence of the Drosophila virilis 60 A gene, a transforming
RT   growth factor-beta superfamily member related to vertebrate bone
RT   morphogenetic proteins.";
RL   Biochim. Biophys. Acta 1307:273-279(1996).
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; U48595; AAC47262.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q24735; -.
DR   SMR; Q24735; -.
DR   STRING; 7244.FBpp0236284; -.
DR   PRIDE; Q24735; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   ChiTaRS; Gbeta13F; fly.
DR   GO; GO:0031045; C:dense core granule; IEA:EnsemblMetazoa.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0036099; P:female germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR   GO; GO:0007504; P:larval fat body development; IEA:EnsemblMetazoa.
DR   GO; GO:0099558; P:maintenance of synapse structure; IEA:EnsemblMetazoa.
DR   GO; GO:0007528; P:neuromuscular junction development; IEA:EnsemblMetazoa.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR   GO; GO:0030707; P:ovarian follicle cell development; IEA:EnsemblMetazoa.
DR   GO; GO:0048636; P:positive regulation of muscle organ development; IEA:EnsemblMetazoa.
DR   GO; GO:0045887; P:positive regulation of synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR   GO; GO:0050806; P:positive regulation of synaptic transmission; IEA:EnsemblMetazoa.
DR   GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
DR   GO; GO:0046928; P:regulation of neurotransmitter secretion; IEA:EnsemblMetazoa.
DR   GO; GO:2000736; P:regulation of stem cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0098917; P:retrograde trans-synaptic signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0035222; P:wing disc pattern formation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; PTHR11848; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..317
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033662"
FT   CHAIN           318..436
FT                   /note="Protein 60A"
FT                   /id="PRO_0000033663"
FT   REGION          293..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        377
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        335..401
FT                   /evidence="ECO:0000250"
FT   DISULFID        364..433
FT                   /evidence="ECO:0000250"
FT   DISULFID        368..435
FT                   /evidence="ECO:0000250"
FT   DISULFID        400
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   436 AA;  49999 MW;  C744B4AE58796692 CRC64;
     MTASLVVLPS LWLILIIFTA PYTHCTQSGI YIDNGKDQTV MERVLTDDDK LDVSHEILEF
     LGIAARPLHH KSHGLSLRKS APKFLLDVYY RITAEEGLAI KNKSDHSRSK RDANESEQNF
     ITDLDKRAID ESDIIMTFLN KRNHNVEEMR HEHGRRLWFD VNNIPTDNYL MMAELRIYQN
     SNEGKWTTTN KQFTVTVYML RSGGSAPNML EPLSSVNTTG DYVGWLELNV TEALHDWRVN
     SNENHGIYIG AHALNKPERE IKLDDIGLIH RRTKVDDENQ PFMIGFFRGP ELIKSTSGHS
     TQKRTKRSTL HQRKKSKSEP VNPFIENSIE NTRSCQMQTL YIDFKDLGWH DWIIAPEGYG
     AFYCSGECNF PLNAHMNATN HAIVQTLVHL LEPKRVPKPC CAPTRLGALP VLYHLNDENV
     NLKKYRNMIV KSCGCH