ID   ARGP_YERPE              Reviewed;         302 AA.
AC   P58510; Q0WIC4;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=HTH-type transcriptional regulator ArgP {ECO:0000255|HAMAP-Rule:MF_00513};
GN   Name=argP {ECO:0000255|HAMAP-Rule:MF_00513}; Synonyms=iciA;
GN   OrderedLocusNames=YPO0916, y3303, YP_3613;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Controls the transcription of genes involved in arginine and
CC       lysine metabolism. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00513}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM86853.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS63763.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL19583.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM86853.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS63763.1; ALT_INIT; Genomic_DNA.
DR   PIR; AE0112; AE0112.
DR   RefSeq; WP_002209958.1; NZ_WUCM01000038.1.
DR   RefSeq; YP_002345964.1; NC_003143.1.
DR   AlphaFoldDB; P58510; -.
DR   SMR; P58510; -.
DR   STRING; 214092.YPO0916; -.
DR   PaxDb; P58510; -.
DR   EnsemblBacteria; AAM86853; AAM86853; y3303.
DR   EnsemblBacteria; AAS63763; AAS63763; YP_3613.
DR   GeneID; 66844378; -.
DR   KEGG; ype:YPO0916; -.
DR   KEGG; ypk:y3303; -.
DR   KEGG; ypm:YP_3613; -.
DR   PATRIC; fig|214092.21.peg.1191; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_063829_0_0_6; -.
DR   OMA; QQWKLDS; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00513; HTH_type_ArgP; 1.
DR   InterPro; IPR017685; ArgP.
DR   InterPro; IPR023490; ArgP_Gammaproteobact.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR03298; argP; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..302
FT                   /note="HTH-type transcriptional regulator ArgP"
FT                   /id="PRO_0000105653"
FT   DOMAIN          4..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00513"
SQ   SEQUENCE   302 AA;  33892 MW;  B887E1812782097C CRC64;
     MKRPDYRTLQ ALDAVIRERG FERAAQKLCI TQSAVSQRIK QLENLFGQPL LVRTVPPRPT
     EQGQKLLALL HQVELLEEEW LGNDNGVDTP LLLSLAVNAD SLATWLLPAL KPVLADLPIR
     LNLQVEDETR TQERLRRGEV VGAVSIQPQP LPSCLVDQLG ALDYLFVASK AFAERYFPNG
     VTRSALLKAP AVAFDHLDDM HQAFLQQNFD LSPGSVPCHI VNSSEAFVQL ARQGTTCCMI
     PHLQIEKELA SGELIDLTPG LLQRRMLFWH RFAPESRTMR KVTDALLSYG RQVLRQDSFI
     GQ