MCD1_CAEEL
ID MCD1_CAEEL Reviewed; 901 AA.
AC B7FAS0; B7FAS1;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Modifier of cell death {ECO:0000312|WormBase:Y51H1A.6a};
GN Name=mcd-1 {ECO:0000312|WormBase:Y51H1A.6a};
GN ORFNames=Y51H1A.6 {ECO:0000312|WormBase:Y51H1A.6a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF HIS-277.
RX PubMed=17237514; DOI=10.1534/genetics.106.068148;
RA Reddien P.W., Andersen E.C., Huang M.C., Horvitz H.R.;
RT "DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein
RT to promote programmed cell death in Caenorhabditis elegans.";
RL Genetics 175:1719-1733(2007).
CC -!- FUNCTION: Promotes programmed cell death. Its role in programmed cell
CC death may be in conjunction with cell cycle regulatory factor efl-1 and
CC the synthetic multivulva class B proteins dpl-1 and lin-35, and is
CC independent of the ced-1, ced-8 and ced-9 pathways.
CC {ECO:0000269|PubMed:17237514}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:Y51H1A.6a};
CC IsoId=B7FAS0-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:Y51H1A.6b};
CC IsoId=B7FAS0-2; Sequence=VSP_059021;
CC -!- DISRUPTION PHENOTYPE: Enhances the cell death defect of ced-3(n2427)
CC mutants. Double knockout with the synthetic multivulva (synMuv) class B
CC proteins lin-9, lin-15B, lin-35 or lin-54 results in 100% lethality
CC during the L1 stage of larval development. Double knockout with the
CC synMuv class B protein lin-53 results in slow larval growth.
CC {ECO:0000269|PubMed:17237514}.
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DR EMBL; BX284602; CAT01087.1; -; Genomic_DNA.
DR EMBL; BX284602; CAT01089.1; -; Genomic_DNA.
DR RefSeq; NP_001254412.1; NM_001267483.1. [B7FAS0-1]
DR RefSeq; NP_001254413.1; NM_001267484.1. [B7FAS0-2]
DR AlphaFoldDB; B7FAS0; -.
DR STRING; 6239.Y51H1A.6a; -.
DR EPD; B7FAS0; -.
DR PaxDb; B7FAS0; -.
DR PeptideAtlas; B7FAS0; -.
DR EnsemblMetazoa; Y51H1A.6a.1; Y51H1A.6a.1; WBGene00013096. [B7FAS0-1]
DR EnsemblMetazoa; Y51H1A.6b.1; Y51H1A.6b.1; WBGene00013096. [B7FAS0-2]
DR GeneID; 175040; -.
DR KEGG; cel:CELE_Y51H1A.6; -.
DR CTD; 175040; -.
DR WormBase; Y51H1A.6a; CE43312; WBGene00013096; mcd-1. [B7FAS0-1]
DR WormBase; Y51H1A.6b; CE43386; WBGene00013096; mcd-1. [B7FAS0-2]
DR eggNOG; ENOG502TI5V; Eukaryota.
DR HOGENOM; CLU_311977_0_0_1; -.
DR InParanoid; B7FAS0; -.
DR OMA; QHIHYDG; -.
DR OrthoDB; 1318335at2759; -.
DR PRO; PR:B7FAS0; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00013096; Expressed in embryo and 4 other tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0002119; P:nematode larval development; IGI:WormBase.
DR GO; GO:0040010; P:positive regulation of growth rate; IGI:WormBase.
DR GO; GO:0012501; P:programmed cell death; IMP:WormBase.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..901
FT /note="Modifier of cell death"
FT /evidence="ECO:0000305"
FT /id="PRO_0000441014"
FT ZN_FING 259..282
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 147..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..642
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_059021"
FT MUTAGEN 277
FT /note="H->Y: In n3376; defective programmed cell death."
FT /evidence="ECO:0000269|PubMed:17237514"
SQ SEQUENCE 901 AA; 102644 MW; E6300EC14257A7E6 CRC64;
METAPDEAPT EFLEPGEEIV ENVIEEEVVH EEDVEHHEED GEMIEVQHEE VLEEIVEEDG
MMFDTDGRVI EYSDVMVYEE GTEVIEEYVE VEDLGDGRYA YVMTDDIGHR RLLKPHEVEA
VKKMPGMMEE EVVMDDEKAP NTSYAAAQKR GRFPPQARSS LSPQKPRAAG AYMGPEAYYQ
QPKRMTHMAK VDVEKYSPVT PVNRRPLMDN AIFKSKLPRK SAPWQEETAA NGGPQSTSLI
RSPSPMLKEP LFDDNEIRFK CAECGDGFPV MDRLCDHMIK QHDCQTNVRE VQFFADRDFE
NFLLKVEKAT LGRDPEDAIR KKSRAGSSQL FVCNYMNKGR QKMAELVEVG IVGLSERPLE
VCTAFVQKTH GYECIRVKYC DQHIHYDGNI GFRVPIAVKR RLFEMSFKRL PIPCMQIMLG
LEAEQLLPHP TRFEEKLKNL SHVEIIELLQ IINASLRKHQ EVEPRGKKVP IKFETIKSSE
GSQTLMVKRV TPPKKEHMDY DEPDPNIPST SAQALGYNPD DDEGDDVPMM SREEEVLDDE
TGEESVMTED CDGMMEDNML YDPENNRDPL FDELTEVELG VLDAYEHDIE IALTEAQKKE
RTRLKAKFAL NKVIGIYQTL DTATHGLTAG ELHTDTINHL RDMASYVVEL VCQIDAEVKV
RRNPALRIDD VKRDMIAGIA MQERVHQPER RPRRSAAPAS PAKPQYRPQP PARSHEEYTQ
RIMNKVKEYM PRRRPDAYDL QQGQQQSRLQ MLREQTLLRA PLEEEKPPVA TMAPVPDEHK
AIPWTRPGRK RAMGPGEAAT APAKRRGRPT KKEEAAEAAA KLIQAENEMV VEEEEVEEPP
VVEQEQVPKE KEVEVAEAEK LPEQVKTEPS VTPSSAPPTP ATTATKTRTG RVVKPKKWDD
N
