ID   MCDP_APICC              Reviewed;          50 AA.
AC   Q6H2Z4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Mast cell degranulating peptide;
DE   Flags: Precursor;
OS   Apis cerana cerana (Oriental honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=94128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=14577379;
RA   Zhang S.F., Shi W.J., Cheng J.A., Zhang C.X.;
RT   "Cloning and characterization analysis of the genes encoding precursor of
RT   mast cell degranulating peptide from 2 honeybee and 3 wasp species.";
RL   Yi Chuan Xue Bao 30:861-866(2003).
CC   -!- FUNCTION: Potent anti-inflammatory agent. At low concentrations,
CC       mediates the degranulation of mast cells thus evoking an inflammatory
CC       response. Also acts as a neurotoxin capable of blocking a class of
CC       voltage-gated potassium channels.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR   EMBL; AY327447; AAQ94692.1; -; mRNA.
DR   AlphaFoldDB; Q6H2Z4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR   InterPro; IPR035361; Bee_toxin.
DR   Pfam; PF17454; Bee_toxin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Disulfide bond; Formylation; Ion channel impairing toxin;
KW   Mast cell degranulation; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         28..49
FT                   /note="Mast cell degranulating peptide"
FT                   /id="PRO_0000247529"
FT   MOD_RES         29
FT                   /note="N6-formyllysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         44
FT                   /note="N6-formyllysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         48
FT                   /note="N6-formyllysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         49
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..42
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   50 AA;  5820 MW;  98487D94D68B0315 CRC64;
     MISMLRCTFF FVSVILITSY FVTPTMSIKC NRKRHVIKPH ICRKICGKNG