ID   MCDP_BOMPE              Reviewed;          28 AA.
AC   P04567;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Mast cell degranulating peptide;
DE            Short=MCD peptide;
DE            Short=MCDP;
OS   Bombus pensylvanicus (American bumblebee) (Apis pensylvanica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Bombus; Fervidobombus.
OX   NCBI_TaxID=28643;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RA   Argiolas A., Herring P., Pisano J.J.;
RT   "Amino acid sequence of bumblebee MCD peptide: a new mast cell
RT   degranulating peptide from the venom of the bumblebee Megabombus
RT   pennsylvanicus.";
RL   Peptides 6 Suppl. 3:431-436(1985).
CC   -!- FUNCTION: Mast cell degranulating peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR   PIR; JW0019; JW0019.
DR   AlphaFoldDB; P04567; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Mast cell degranulation;
KW   Secreted.
FT   PEPTIDE         1..28
FT                   /note="Mast cell degranulating peptide"
FT                   /id="PRO_0000044064"
FT   DISULFID        2..18
FT   DISULFID        4..22
SQ   SEQUENCE   28 AA;  3180 MW;  3D049AB655E2EF3D CRC64;
     MCICKNGKPL PGFIGKICRK ICMMQQTH