MCEE_BOVIN
ID MCEE_BOVIN Reviewed; 175 AA.
AC Q2KIZ3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Methylmalonyl-CoA epimerase, mitochondrial {ECO:0000305};
DE EC=5.1.99.1 {ECO:0000250|UniProtKB:Q96PE7};
DE AltName: Full=DL-methylmalonyl-CoA racemase;
DE Flags: Precursor;
GN Name=MCEE;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Methylmalonyl-CoA epimerase involved in propionyl-CoA
CC metabolism. {ECO:0000250|UniProtKB:Q96PE7}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA;
CC Xref=Rhea:RHEA:20553, ChEBI:CHEBI:57326, ChEBI:CHEBI:57327;
CC EC=5.1.99.1; Evidence={ECO:0000250|UniProtKB:Q96PE7};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:20555;
CC Evidence={ECO:0000250|UniProtKB:Q96PE7};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA epimerase family.
CC {ECO:0000305}.
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DR EMBL; BC112453; AAI12454.1; -; mRNA.
DR RefSeq; NP_001039460.1; NM_001045995.2.
DR AlphaFoldDB; Q2KIZ3; -.
DR SMR; Q2KIZ3; -.
DR STRING; 9913.ENSBTAP00000046594; -.
DR PaxDb; Q2KIZ3; -.
DR PeptideAtlas; Q2KIZ3; -.
DR PRIDE; Q2KIZ3; -.
DR GeneID; 508170; -.
DR KEGG; bta:508170; -.
DR CTD; 84693; -.
DR eggNOG; KOG2944; Eukaryota.
DR HOGENOM; CLU_046006_5_0_1; -.
DR InParanoid; Q2KIZ3; -.
DR OrthoDB; 1543116at2759; -.
DR TreeFam; TF313417; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004493; F:methylmalonyl-CoA epimerase activity; IBA:GO_Central.
DR GO; GO:0046491; P:L-methylmalonyl-CoA metabolic process; IBA:GO_Central.
DR CDD; cd07249; MMCE; 1.
DR Gene3D; 3.10.180.10; -; 1.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR017515; MeMalonyl-CoA_epimerase.
DR InterPro; IPR037523; VOC.
DR SUPFAM; SSF54593; SSF54593; 1.
DR TIGRFAMs; TIGR03081; metmalonyl_epim; 1.
DR PROSITE; PS51819; VOC; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cobalt; Isomerase; Metal-binding; Mitochondrion;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 36..175
FT /note="Methylmalonyl-CoA epimerase, mitochondrial"
FT /id="PRO_0000240349"
FT DOMAIN 46..175
FT /note="VOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT BINDING 49
FT /ligand="Co(2+)"
FT /ligand_id="ChEBI:CHEBI:48828"
FT /evidence="ECO:0000250"
FT BINDING 121
FT /ligand="Co(2+)"
FT /ligand_id="ChEBI:CHEBI:48828"
FT /evidence="ECO:0000250"
FT BINDING 171
FT /ligand="Co(2+)"
FT /ligand_id="ChEBI:CHEBI:48828"
FT /evidence="ECO:0000250"
FT MOD_RES 113
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9D1I5"
FT MOD_RES 149
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9D1I5"
FT MOD_RES 149
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9D1I5"
SQ SEQUENCE 175 AA; 18514 MW; DB8548CD77EAB207 CRC64;
MARVLKVAAA SAAGLFPRLR TPVSTVRTSA SLSSHPGAGP VWNLGRLNHV AVAVPDLEKA
RAFYKNVLGA EVGEPVPLPE HGVSVVFVNL GNTKMELLHP LGSDSPIAGF LKKNKAGGMH
HVCIEVDNIN VAVMDLKEKK IRILSEEAKI GAHGKPVIFL HPSDCGGVLV ELEQA
