MCEM1_HUMAN
ID MCEM1_HUMAN Reviewed; 187 AA.
AC Q8IX19; Q8IX20;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Mast cell-expressed membrane protein 1;
GN Name=MCEMP1; Synonyms=C19orf59;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-167, TOPOLOGY, AND TISSUE
RP SPECIFICITY.
RX PubMed=15953541; DOI=10.1016/j.ygeno.2005.03.006;
RA Li K., Wang S.-W., Li Y., Martin R.E., Li L., Lu M.,
RA Lamhamedi-Cherradi S.-E., Hu G., Demissie-Sanders S., Zheng J., Chung F.,
RA Oates T., Yao Z.;
RT "Identification and expression of a new type II transmembrane protein in
RT human mast cells.";
RL Genomics 86:68-75(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IX19; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-2816356, EBI-714543;
CC Q8IX19; P07306: ASGR1; NbExp=3; IntAct=EBI-2816356, EBI-1172335;
CC Q8IX19; P07307-3: ASGR2; NbExp=3; IntAct=EBI-2816356, EBI-12808270;
CC Q8IX19; P27449: ATP6V0C; NbExp=5; IntAct=EBI-2816356, EBI-721179;
CC Q8IX19; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-2816356, EBI-11522780;
CC Q8IX19; O95406: CNIH1; NbExp=3; IntAct=EBI-2816356, EBI-12172273;
CC Q8IX19; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-2816356, EBI-12831978;
CC Q8IX19; Q13021: MALL; NbExp=3; IntAct=EBI-2816356, EBI-750078;
CC Q8IX19; Q8IX19: MCEMP1; NbExp=3; IntAct=EBI-2816356, EBI-2816356;
CC Q8IX19; O60831: PRAF2; NbExp=3; IntAct=EBI-2816356, EBI-2506064;
CC Q8IX19; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-2816356, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed specifically in mast cells. Found
CC primarily in lung. {ECO:0000269|PubMed:15953541}.
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DR EMBL; AF461155; AAO15597.1; -; mRNA.
DR EMBL; AF461156; AAO15598.1; -; mRNA.
DR EMBL; AC008763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104796; AAI04797.1; -; mRNA.
DR EMBL; BC104798; AAI04799.1; -; mRNA.
DR RefSeq; NP_777578.2; NM_174918.2.
DR AlphaFoldDB; Q8IX19; -.
DR SMR; Q8IX19; -.
DR BioGRID; 128261; 33.
DR IntAct; Q8IX19; 15.
DR STRING; 9606.ENSP00000329920; -.
DR GlyGen; Q8IX19; 1 site.
DR iPTMnet; Q8IX19; -.
DR PhosphoSitePlus; Q8IX19; -.
DR BioMuta; MCEMP1; -.
DR DMDM; 74759647; -.
DR EPD; Q8IX19; -.
DR MassIVE; Q8IX19; -.
DR PaxDb; Q8IX19; -.
DR PeptideAtlas; Q8IX19; -.
DR PRIDE; Q8IX19; -.
DR ProteomicsDB; 70967; -.
DR Antibodypedia; 2676; 28 antibodies from 16 providers.
DR DNASU; 199675; -.
DR Ensembl; ENST00000333598.8; ENSP00000329920.3; ENSG00000183019.8.
DR GeneID; 199675; -.
DR KEGG; hsa:199675; -.
DR UCSC; uc002mhh.2; human.
DR CTD; 199675; -.
DR DisGeNET; 199675; -.
DR GeneCards; MCEMP1; -.
DR HGNC; HGNC:27291; MCEMP1.
DR HPA; ENSG00000183019; Group enriched (bone marrow, lung, lymphoid tissue).
DR MIM; 609565; gene.
DR neXtProt; NX_Q8IX19; -.
DR PharmGKB; PA162378700; -.
DR VEuPathDB; HostDB:ENSG00000183019; -.
DR eggNOG; ENOG502RTYW; Eukaryota.
DR HOGENOM; CLU_125266_0_0_1; -.
DR InParanoid; Q8IX19; -.
DR OMA; KHQEVKM; -.
DR OrthoDB; 1529922at2759; -.
DR PhylomeDB; Q8IX19; -.
DR TreeFam; TF337063; -.
DR PathwayCommons; Q8IX19; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q8IX19; -.
DR BioGRID-ORCS; 199675; 11 hits in 1069 CRISPR screens.
DR GenomeRNAi; 199675; -.
DR Pharos; Q8IX19; Tdark.
DR PRO; PR:Q8IX19; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IX19; protein.
DR Bgee; ENSG00000183019; Expressed in monocyte and 106 other tissues.
DR ExpressionAtlas; Q8IX19; baseline and differential.
DR Genevisible; Q8IX19; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR038818; MCEMP1.
DR PANTHER; PTHR37856; PTHR37856; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..187
FT /note="Mast cell-expressed membrane protein 1"
FT /id="PRO_0000274052"
FT TOPO_DOM 1..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 49..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 129
FT /note="V -> I (in dbSNP:rs8111596)"
FT /id="VAR_059697"
FT VARIANT 167
FT /note="I -> V (in dbSNP:rs72996468)"
FT /evidence="ECO:0000269|PubMed:15953541"
FT /id="VAR_030180"
FT VARIANT 175
FT /note="L -> V (in dbSNP:rs10409343)"
FT /id="VAR_051159"
SQ SEQUENCE 187 AA; 21229 MW; E7D910214BF6BDD3 CRC64;
MEVEEIYKHQ EVKMQAPAFR DKKQGVSAKN QGAHDPDYEN ITLAFKNQDH AKGGHSRPTS
QVPAQCRPPS DSTQVPCWLY RAILSLYILL ALAFVLCIIL SAFIMVKNAE MSKELLGFKR
ELWNVSNSVQ ACEERQKRGW DSVQQSITMV RSKIDRLETT LAGIKNIDTK VQKILEVLQK
MPQSSPQ
