MCEM1_MOUSE
ID MCEM1_MOUSE Reviewed; 183 AA.
AC Q9D8U6;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Mast cell-expressed membrane protein 1;
GN Name=Mcemp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, Lung, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
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DR EMBL; AK007679; BAB25183.1; -; mRNA.
DR EMBL; AK036449; BAC29434.1; -; mRNA.
DR EMBL; AK087121; BAC39808.1; -; mRNA.
DR EMBL; AC087183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466566; EDL21944.1; -; Genomic_DNA.
DR CCDS; CCDS22069.1; -.
DR RefSeq; NP_081261.1; NM_026985.1.
DR AlphaFoldDB; Q9D8U6; -.
DR SMR; Q9D8U6; -.
DR STRING; 10090.ENSMUSP00000014118; -.
DR GlyGen; Q9D8U6; 1 site.
DR iPTMnet; Q9D8U6; -.
DR PhosphoSitePlus; Q9D8U6; -.
DR MaxQB; Q9D8U6; -.
DR PaxDb; Q9D8U6; -.
DR PRIDE; Q9D8U6; -.
DR ProteomicsDB; 252742; -.
DR Antibodypedia; 2676; 28 antibodies from 16 providers.
DR DNASU; 69189; -.
DR Ensembl; ENSMUST00000014118; ENSMUSP00000014118; ENSMUSG00000013974.
DR GeneID; 69189; -.
DR KEGG; mmu:69189; -.
DR UCSC; uc009ksi.1; mouse.
DR CTD; 199675; -.
DR MGI; MGI:1916439; Mcemp1.
DR VEuPathDB; HostDB:ENSMUSG00000013974; -.
DR eggNOG; ENOG502RTYW; Eukaryota.
DR GeneTree; ENSGT00390000007959; -.
DR HOGENOM; CLU_125266_0_0_1; -.
DR InParanoid; Q9D8U6; -.
DR OMA; KHQEVKM; -.
DR OrthoDB; 1529922at2759; -.
DR PhylomeDB; Q9D8U6; -.
DR TreeFam; TF337063; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 69189; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q9D8U6; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D8U6; protein.
DR Bgee; ENSMUSG00000013974; Expressed in granulocyte and 40 other tissues.
DR Genevisible; Q9D8U6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR038818; MCEMP1.
DR PANTHER; PTHR37856; PTHR37856; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..183
FT /note="Mast cell-expressed membrane protein 1"
FT /id="PRO_0000358923"
FT TOPO_DOM 1..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 183 AA; 20649 MW; 43B793F948DE9B35 CRC64;
MHASASQDKN RRKPGHDEGA HNPDYENITL AFRNKDQLKL SQSTPTKQAK FKTSLDPAES
PPWLYRTIMM LYVLLALVFL SCIVLSALVL VKNSEMSKEL WTLKAELSNV SDTVWNIREL
QNQQTRIWEA AQGDIKEVKK TLGTVMSSIQ TGNDRLKTVP ADITQIKKTL EALEKKAQPQ
PST
