MCES_FOWPN
ID MCES_FOWPN Reviewed; 289 AA.
AC O72908;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 29-SEP-2021, entry version 85.
DE RecName: Full=mRNA-capping enzyme small subunit;
DE AltName: Full=mRNA (guanine-N(7))-methyltransferase;
DE EC=2.1.1.56;
DE AltName: Full=mRNA cap methyltransferase;
GN OrderedLocusNames=FPV051; ORFNames=FP-D12, FPD12;
OS Fowlpox virus (strain NVSL) (FPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX NCBI_TaxID=928301;
OH NCBI_TaxID=7742; Vertebrata.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FP-9 / Isolate HP-440;
RA Skinner M.A.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2177083; DOI=10.1099/0022-1317-71-12-2873;
RA Binns M.M., Britton B.S., Mason C., Boursnell M.E.G.;
RT "Analysis of the fowlpox virus genome region corresponding to the vaccinia
RT virus D6 to A1 region: location of, and variation in, non-essential genes
RT in poxviruses.";
RL J. Gen. Virol. 71:2873-2881(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT "The genome of fowlpox virus.";
RL J. Virol. 74:3815-3831(2000).
CC -!- FUNCTION: Catalyzes the last reaction in the mRNA cap formation
CC pathway.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC ChEBI:CHEBI:167617; EC=2.1.1.56;
CC -!- SUBUNIT: Heterodimer of a large and a small subunit.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=All the enzymes and
CC other proteins required to synthesize early mRNAs are packaged within
CC the virion core along with the DNA genome.
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DR EMBL; AJ005163; CAA06402.1; -; Genomic_DNA.
DR EMBL; AF198100; AAF44395.1; -; Genomic_DNA.
DR PIR; S42252; S42252.
DR RefSeq; NP_039014.1; NC_002188.1.
DR SMR; O72908; -.
DR PRIDE; O72908; -.
DR GeneID; 1486599; -.
DR KEGG; vg:1486599; -.
DR Proteomes; UP000008597; Genome.
DR GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.11680; -; 1.
DR InterPro; IPR005009; Poxvirus_mRNA-cap_ssu.
DR InterPro; IPR043096; Poxvirus_mRNA-cap_ssu_sf.
DR Pfam; PF03341; Pox_mRNA-cap; 1.
PE 4: Predicted;
KW Methyltransferase; mRNA capping; mRNA processing; Reference proteome;
KW S-adenosyl-L-methionine; Transferase; Virion.
FT CHAIN 1..289
FT /note="mRNA-capping enzyme small subunit"
FT /id="PRO_0000210139"
SQ SEQUENCE 289 AA; 33867 MW; ADCEFC32AA71B131 CRC64;
MNTDRITAFI KNGISARMPF YDTLPDMDLV FGKNHLPSLE YGANYFLQLS KINDINRLST
EMLSLYTHDL NKESDISKLF EPYNIKTIKS YGRSIQADAV VVDLRPSNSL YKNEHPYYKS
NNYLKENNLY ICDYTMITFE IYRPIFELST EKTCIIKVPT LFGKTIVNAV RVYCSLFRYV
KLYKLSADSW LKDSAIIVCQ QPHAANINKF ITYIRKVTKS QTWLDSNNVN FILIHDSVER
VFIEKFLSFS YKIYESLYYV HSLLYSSMTS DLQSLDNEYQ KKLIKLLRG
