MCES_SWPVK
ID MCES_SWPVK Reviewed; 287 AA.
AC Q08512;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 29-SEP-2021, entry version 71.
DE RecName: Full=mRNA-capping enzyme small subunit;
DE AltName: Full=mRNA (guanine-N(7))-methyltransferase;
DE EC=2.1.1.56;
DE AltName: Full=mRNA cap methyltransferase;
OS Swinepox virus (strain Kasza) (SWPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Suipoxvirus.
OX NCBI_TaxID=10277;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8249275; DOI=10.1006/viro.1993.1625;
RA Massung R.F., Jayarama V., Moyer R.W.;
RT "DNA sequence analysis of conserved and unique regions of swinepox virus:
RT identification of genetic elements supporting phenotypic observations
RT including a novel G protein-coupled receptor homologue.";
RL Virology 197:511-528(1993).
CC -!- FUNCTION: Catalyzes the last reaction in the mRNA cap formation
CC pathway.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC ChEBI:CHEBI:167617; EC=2.1.1.56;
CC -!- SUBUNIT: Heterodimer of a large and a small subunit.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=All the enzymes and
CC other proteins required to synthesize early mRNAs are packaged within
CC the virion core along with the DNA genome.
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DR EMBL; L22012; AAA16177.1; -; Unassigned_DNA.
DR RefSeq; NP_570246.1; NC_003389.1.
DR SMR; Q08512; -.
DR GeneID; 932372; -.
DR KEGG; vg:932372; -.
DR GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.11680; -; 1.
DR InterPro; IPR005009; Poxvirus_mRNA-cap_ssu.
DR InterPro; IPR043096; Poxvirus_mRNA-cap_ssu_sf.
DR Pfam; PF03341; Pox_mRNA-cap; 1.
PE 4: Predicted;
KW Methyltransferase; mRNA capping; mRNA processing; S-adenosyl-L-methionine;
KW Transferase; Virion.
FT CHAIN 1..287
FT /note="mRNA-capping enzyme small subunit"
FT /id="PRO_0000210140"
SQ SEQUENCE 287 AA; 33488 MW; 4B6AE6A93028DD21 CRC64;
MDKITRNIRE GIHILLPFYE NLPDISLSLG KSPLPSLEYG TNYFLQLSRV NDLNRLPTDM
LSLFTHDIML PETDMEKVYD ILNIKSVKSY GKSIKADAVV ADLSARNRLF KKDRELIKSN
NYLTDNNLYI SDYKMLTFEV FRPLFDLSSE KYCIVKLPTL FGKCVIDTIR VYCSLFKSVR
LFKCASDSWL KDSAIMVASD IYKKNIDIFM SHIRSVLKSQ YWKDSNNVQF SILKESVDKE
FINKFLEFST SVYESLYYVH SLLYSSMISD NKSIENEYQK KLTKLLL