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MCES_SWPVK
ID   MCES_SWPVK              Reviewed;         287 AA.
AC   Q08512;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   29-SEP-2021, entry version 71.
DE   RecName: Full=mRNA-capping enzyme small subunit;
DE   AltName: Full=mRNA (guanine-N(7))-methyltransferase;
DE            EC=2.1.1.56;
DE   AltName: Full=mRNA cap methyltransferase;
OS   Swinepox virus (strain Kasza) (SWPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Suipoxvirus.
OX   NCBI_TaxID=10277;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8249275; DOI=10.1006/viro.1993.1625;
RA   Massung R.F., Jayarama V., Moyer R.W.;
RT   "DNA sequence analysis of conserved and unique regions of swinepox virus:
RT   identification of genetic elements supporting phenotypic observations
RT   including a novel G protein-coupled receptor homologue.";
RL   Virology 197:511-528(1993).
CC   -!- FUNCTION: Catalyzes the last reaction in the mRNA cap formation
CC       pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC         S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC         triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC         COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC         ChEBI:CHEBI:167617; EC=2.1.1.56;
CC   -!- SUBUNIT: Heterodimer of a large and a small subunit.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=All the enzymes and
CC       other proteins required to synthesize early mRNAs are packaged within
CC       the virion core along with the DNA genome.
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DR   EMBL; L22012; AAA16177.1; -; Unassigned_DNA.
DR   RefSeq; NP_570246.1; NC_003389.1.
DR   SMR; Q08512; -.
DR   GeneID; 932372; -.
DR   KEGG; vg:932372; -.
DR   GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.11680; -; 1.
DR   InterPro; IPR005009; Poxvirus_mRNA-cap_ssu.
DR   InterPro; IPR043096; Poxvirus_mRNA-cap_ssu_sf.
DR   Pfam; PF03341; Pox_mRNA-cap; 1.
PE   4: Predicted;
KW   Methyltransferase; mRNA capping; mRNA processing; S-adenosyl-L-methionine;
KW   Transferase; Virion.
FT   CHAIN           1..287
FT                   /note="mRNA-capping enzyme small subunit"
FT                   /id="PRO_0000210140"
SQ   SEQUENCE   287 AA;  33488 MW;  4B6AE6A93028DD21 CRC64;
     MDKITRNIRE GIHILLPFYE NLPDISLSLG KSPLPSLEYG TNYFLQLSRV NDLNRLPTDM
     LSLFTHDIML PETDMEKVYD ILNIKSVKSY GKSIKADAVV ADLSARNRLF KKDRELIKSN
     NYLTDNNLYI SDYKMLTFEV FRPLFDLSSE KYCIVKLPTL FGKCVIDTIR VYCSLFKSVR
     LFKCASDSWL KDSAIMVASD IYKKNIDIFM SHIRSVLKSQ YWKDSNNVQF SILKESVDKE
     FINKFLEFST SVYESLYYVH SLLYSSMISD NKSIENEYQK KLTKLLL
 
 
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