ID   MCES_YMTV5              Reviewed;         287 AA.
AC   Q9QB92;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   29-SEP-2021, entry version 70.
DE   RecName: Full=mRNA-capping enzyme small subunit;
DE   AltName: Full=mRNA (guanine-N(7))-methyltransferase;
DE            EC=2.1.1.56;
DE   AltName: Full=mRNA cap methyltransferase;
GN   OrderedLocusNames=89L; ORFNames=B6L;
OS   Yaba monkey tumor virus (strain VR587) (YMTV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=928314;
OH   NCBI_TaxID=9538; Erythrocebus patas (Red guenon) (Cercopithecus patas).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9539; Macaca (macaques).
OH   NCBI_TaxID=9557; Papio hamadryas (Hamadryas baboon).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14645589; DOI=10.1128/jvi.77.24.13335-13347.2003;
RA   Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X.,
RA   Barrett J.W., McFadden G.;
RT   "Complete genomic sequence and comparative analysis of the tumorigenic
RT   poxvirus Yaba monkey tumor virus.";
RL   J. Virol. 77:13335-13347(2003).
CC   -!- FUNCTION: Catalyzes the last reaction in the mRNA cap formation
CC       pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC         S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC         triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC         COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC         ChEBI:CHEBI:167617; EC=2.1.1.56;
CC   -!- SUBUNIT: Heterodimer of a large and a small subunit.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=All the enzymes and
CC       other proteins required to synthesize early mRNAs are packaged within
CC       the virion core along with the DNA genome.
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DR   EMBL; AY386371; AAR07445.1; -; Genomic_DNA.
DR   RefSeq; NP_938344.1; NC_005179.1.
DR   SMR; Q9QB92; -.
DR   GeneID; 2943587; -.
DR   KEGG; vg:2943587; -.
DR   Proteomes; UP000008596; Genome.
DR   GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.11680; -; 1.
DR   InterPro; IPR005009; Poxvirus_mRNA-cap_ssu.
DR   InterPro; IPR043096; Poxvirus_mRNA-cap_ssu_sf.
DR   Pfam; PF03341; Pox_mRNA-cap; 1.
PE   4: Predicted;
KW   Methyltransferase; mRNA capping; mRNA processing; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; Virion.
FT   CHAIN           1..287
FT                   /note="mRNA-capping enzyme small subunit"
FT                   /id="PRO_0000210141"
SQ   SEQUENCE   287 AA;  33391 MW;  5C841F091325E807 CRC64;
     MDQIAKCIKE GTHTLFPFYD NLPDVNLFLG NSPLPSLEYG ANYFLQLSRV NDLNRLPTDL
     LSLFTHEIMV QENDLEKVYD ILNIHSVKSY GKTIKADAVV IDLSAKNKLF KKDRELIKSN
     NYLTENNLYI SDYKMLTFEV FRPLFEMSSE KYCIIKLPTL FGRCVIDTTR VYCSLFKSVR
     LFKCANDSWL KDSAIIVASN ACKKNIDYFM SHIRSVTKSL NWKESNNVQF SILKDSVDKE
     FIDKFLNFST KVYESLYYVH SLLYSSMTSE SKSIENEYQK KLTKLLL