ID   ARGR1_STRP1             Reviewed;         157 AA.
AC   Q99YT5; Q48XN0;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=Arginine regulator;
GN   Name=argR1; OrderedLocusNames=SPy_1549, M5005_Spy1277;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Regulates the transcription of the arc operon, involved in
CC       arginine catabolism. {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK34341.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51895.1; -; Genomic_DNA.
DR   RefSeq; NP_269620.1; NC_002737.2.
DR   AlphaFoldDB; Q99YT5; -.
DR   SMR; Q99YT5; -.
DR   STRING; 1314.HKU360_01318; -.
DR   PaxDb; Q99YT5; -.
DR   EnsemblBacteria; AAK34341; AAK34341; SPy_1549.
DR   KEGG; spy:SPy_1549; -.
DR   KEGG; spz:M5005_Spy1277; -.
DR   PATRIC; fig|160490.10.peg.1354; -.
DR   HOGENOM; CLU_097103_3_1_9; -.
DR   OMA; IMGTICG; -.
DR   UniPathway; UPA00254; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0034618; F:arginine binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00173; Arg_repressor; 1.
DR   InterPro; IPR001669; Arg_repress.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR036251; Arg_repress_C_sf.
DR   InterPro; IPR020900; Arg_repress_DNA-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34471; PTHR34471; 1.
DR   Pfam; PF01316; Arg_repressor; 1.
DR   Pfam; PF02863; Arg_repressor_C; 1.
DR   PRINTS; PR01467; ARGREPRESSOR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55252; SSF55252; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; DNA-binding; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..157
FT                   /note="Arginine regulator"
FT                   /id="PRO_0000205128"
SQ   SEQUENCE   157 AA;  18011 MW;  4B9D8D48B59B87D2 CRC64;
     MNKKETRHQL IRSLISETTI HTQQELQERL QKNGITITQA TLSRDMKELN LVKVTSGNDT
     HYEALAISQT RWEHRLRFYM EDALVMLKIV QHQIILKTLP GLAQSFGSIL DAMQIPEIVA
     TVCGDDTCLI VCEDNEQAKA CYETLSHYTP PFFFSNK