MCFA_DICDI
ID MCFA_DICDI Reviewed; 327 AA.
AC Q54EV4;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Mitochondrial substrate carrier family protein A;
GN Name=mcfA; ORFNames=DDB_G0291312;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier. Mitochondrial
CC solute carriers shuttle metabolites, nucleotides, and cofactors through
CC the mitochondrial inner membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000177; EAL61640.1; -; Genomic_DNA.
DR RefSeq; XP_635136.1; XM_630044.1.
DR AlphaFoldDB; Q54EV4; -.
DR SMR; Q54EV4; -.
DR PaxDb; Q54EV4; -.
DR EnsemblProtists; EAL61640; EAL61640; DDB_G0291312.
DR GeneID; 8628082; -.
DR KEGG; ddi:DDB_G0291312; -.
DR dictyBase; DDB_G0291312; mcfA.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; Q54EV4; -.
DR OMA; VHESPPF; -.
DR PhylomeDB; Q54EV4; -.
DR Reactome; R-DDI-196783; Coenzyme A biosynthesis.
DR PRO; PR:Q54EV4; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..327
FT /note="Mitochondrial substrate carrier family protein A"
FT /id="PRO_0000385517"
FT TOPO_DOM 1..48
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 49..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..106
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 107..127
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..145
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 146..166
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..192
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 193..213
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..238
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 239..259
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..303
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 304..324
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..327
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 43..132
FT /note="Solcar 1"
FT REPEAT 140..224
FT /note="Solcar 2"
FT REPEAT 233..323
FT /note="Solcar 3"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36132 MW; 11216F0E88FEAC0D CRC64;
MVINNQNNNN QNNNQNNNNK NDNLNNSTTT TTTTATTTKS STLFHSNDFF SGLIAGIVSR
TLTAPLERIK ILNQVEVILK DGTKYNRIIP AFKVIIKEEG IAGLFRGNFV NIIKAGPQSA
IRFYSYGAFK RMASEPDGSI SVINRMWAGA SSGVVSVALT HPLDVIKTHI TVIAPTAATI
KNVTKGIYRD LGIIGFFRGL SAGILNIAPF AALNFTFYET IKEKTQQYIL KSPPLYAPSI
YGAISGGLTM TILYPLDVVK RRIMLQHFDR NQLPIYKNFI DAIIKITKTE GISALYKGIR
PAYLKVIPTV SINFLIYEGA ITLFEKK
