ARGR1_STRP6
ID ARGR1_STRP6 Reviewed; 157 AA.
AC Q5XAY0;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Arginine regulator;
GN Name=argR1; OrderedLocusNames=M6_Spy1298;
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394;
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
CC -!- FUNCTION: Regulates the transcription of the arc operon, involved in
CC arginine catabolism. {ECO:0000250}.
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC pathway.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000305}.
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DR EMBL; CP000003; AAT87433.1; -; Genomic_DNA.
DR RefSeq; WP_002989056.1; NC_006086.1.
DR AlphaFoldDB; Q5XAY0; -.
DR SMR; Q5XAY0; -.
DR EnsemblBacteria; AAT87433; AAT87433; M6_Spy1298.
DR KEGG; spa:M6_Spy1298; -.
DR HOGENOM; CLU_097103_3_1_9; -.
DR OMA; IMGTICG; -.
DR UniPathway; UPA00254; -.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0034618; F:arginine binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00173; Arg_repressor; 1.
DR InterPro; IPR001669; Arg_repress.
DR InterPro; IPR020899; Arg_repress_C.
DR InterPro; IPR036251; Arg_repress_C_sf.
DR InterPro; IPR020900; Arg_repress_DNA-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR34471; PTHR34471; 1.
DR Pfam; PF01316; Arg_repressor; 1.
DR Pfam; PF02863; Arg_repressor_C; 1.
DR PRINTS; PR01467; ARGREPRESSOR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF55252; SSF55252; 1.
PE 3: Inferred from homology;
KW Arginine metabolism; Cytoplasm; DNA-binding; Transcription;
KW Transcription regulation.
FT CHAIN 1..157
FT /note="Arginine regulator"
FT /id="PRO_0000205132"
SQ SEQUENCE 157 AA; 18011 MW; 4B9D8D48B59B87D2 CRC64;
MNKKETRHQL IRSLISETTI HTQQELQERL QKNGITITQA TLSRDMKELN LVKVTSGNDT
HYEALAISQT RWEHRLRFYM EDALVMLKIV QHQIILKTLP GLAQSFGSIL DAMQIPEIVA
TVCGDDTCLI VCEDNEQAKA CYETLSHYTP PFFFSNK