ID   MCFD2_PONAB             Reviewed;         146 AA.
AC   Q5R8Z6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Multiple coagulation factor deficiency protein 2 homolog;
DE   Flags: Precursor;
GN   Name=MCFD2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The MCFD2-LMAN1 complex forms a specific cargo receptor for
CC       the ER-to-Golgi transport of selected proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts in a calcium-dependent manner with LMAN1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi
CC       apparatus {ECO:0000250}.
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DR   EMBL; CR858179; CAH90418.1; -; mRNA.
DR   EMBL; CR859601; CAH91764.1; -; mRNA.
DR   RefSeq; NP_001127284.1; NM_001133812.1.
DR   RefSeq; XP_009235607.1; XM_009237332.1.
DR   RefSeq; XP_009235608.1; XM_009237333.1.
DR   RefSeq; XP_009235612.1; XM_009237337.1.
DR   RefSeq; XP_009235613.1; XM_009237338.1.
DR   AlphaFoldDB; Q5R8Z6; -.
DR   BMRB; Q5R8Z6; -.
DR   SMR; Q5R8Z6; -.
DR   STRING; 9601.ENSPPYP00000013885; -.
DR   Ensembl; ENSPPYT00000048350; ENSPPYP00000040669; ENSPPYG00000036629.
DR   GeneID; 100174341; -.
DR   KEGG; pon:100174341; -.
DR   CTD; 90411; -.
DR   eggNOG; KOG4065; Eukaryota.
DR   GeneTree; ENSGT00940000154141; -.
DR   HOGENOM; CLU_1179904_0_0_1; -.
DR   InParanoid; Q5R8Z6; -.
DR   OrthoDB; 1601131at2759; -.
DR   Proteomes; UP000001595; Chromosome 2A.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Metal-binding; Phosphoprotein; Protein transport; Reference proteome;
KW   Repeat; Signal; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..146
FT                   /note="Multiple coagulation factor deficiency protein 2
FT                   homolog"
FT                   /id="PRO_0000240317"
FT   DOMAIN          68..103
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          116..146
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         81
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         83
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         85
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         92
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         129
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         131
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         133
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         135
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         140
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         106
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K5B3"
SQ   SEQUENCE   146 AA;  16390 MW;  EF3F3B28E5C7A8A8 CRC64;
     MTMRSLLRTP FLCGLLWAFC APGARAEEPA ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI
     NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELINI
     IDGVLRDDDK NNDGYIDYAE FAKSLQ